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Clinical Trials in China / NCT06615726
Active, not recruiting Phase 3

Regular Physical Exercise in Patients With Symptomatic Intracranial Arterial Stenosis

NCT06615726 · tracked via the Priya Life Science China tracker
Sponsor
Capital Medical University
Phase
Phase 3
Started
2024-10-10
Last updated
2025-11-25

Condition(s) studied

Ischemic StrokeTransient Ischemic Attack

Investigational drug(s) / intervention(s)

Regular physical exerciseControl group

Regular physical exercise: Best medical treatment plus regular physical exercise. Each subject is equipped with an exercise guidance expert to regularly guide and adjust the exercise plan according to the subject's personal conditions throughout the trial period. After randomization, the exercise guidance expert formulated an individualized aerobic exercise plan based on the subject's preferences and their own exercise abilities. After each exercise, subjects filled out the exercise diary , and reported back to the exercise guidance expert.

Control group: Best medical treatment

Study summary

The objective of this study is to evaluate the effectiveness and safety of regular physical exercise in preventing ischemic stroke events in patients with symptomatic intracranial arterial stenosis.

Eligibility

Sex
ALL
Min age
40 Years
Max age
80 Years
Healthy volunteers
No
1\. Inclusion criteria: 1. Age ≥40 years and ≤80 years; 2. Ischemic stroke or TIA (transient ischemic attack) onset ≤30 days; 3. Ischemic stroke or TIA is attributed to 50-99% of the ICAS (internal carotid artery, M1 segment of middle cerebral artery, M2 segment of middle cerebral artery, basilar artery, or vertebral artery; the degree of stenosis is determined by magnetic resonance angiography, computed tomography angiography, digital subtraction angiography using the standards of warfarin-aspirin symptomatic intracranial disease ); 4. mRS (modified Rankin Scale)≤4; 5. The patient himself or his legal representative signs the informed consent form. 2\. Exclusion criteria: 1. Stroke progression within the past 3 days (defined as an increase in the score of National Institute of Health Stroke Scale ≥4 points or an increase in individual items of ≥2 points). 2. mRS≥1 before the stroke onset. 3. Concurrent osteoarthritis, fracture, lower limb venous thrombosis, unstable angina pectoris, respiratory diseases, limb disabilities, etc., making it theoretically difficult to cooperate with the physical activity plan for this trial. 4. Complicated with motor disorders such as Parkinson\'s disease and Parkinson\'s syndrome. 5. The vessels responsible for this stroke had tandem lesions (more than 50% of extracranial artery stenosis). 6. The vessel responsible for this stroke has undergone intracranial balloon angioplasty and/or stent implantation (except for mechanical thrombectomy and/or aspiration alone). 7. It is expected that intracranial arterial balloon angioplasty and/or stent implantation will be performed on the vessel responsible for the stroke within 3 months. 8. Patients who exercised regularly within the last 6 months. Regular exercise is defined as four or more moderate intensity exercises per week for more than 10 minutes each time or two or more high intensity exercises per week for more than 10 minutes each time. 9. Inability to understand and/or comply with the trial procedures and/or follow-up due to mental illness, cognitive or emotional disorders. 10. Life expectancy is less than one year. 11. Women who are known to be pregnant or nursing, or have a positive pregnancy test; 12. Are participating in other drug or device research. 13. There are other circumstances that investigators consider are not suitable for enrollment.

Primary outcome measure(s)

Trial sites (58)

FacilityCityRegionStatus
Taihe Hospital of Traditional Chinese Medicine Fuyang Anhui
Huainan Sunshine Xinkang Hospital Huainan Anhui
Suzhou Municipal Hospital Suzhou Anhui
The Second People's Hospital of Wuhu Wuhu Anhui
Xuanwu Hospital, Capital Medical University Beijing Beijing Municipality
Beijing Pinggu District Hospital Beijing Beijing Municipality
Chongqing Sanbo Jiangling Hospital Chongqing Chongqing Municipality
Zhangzhou Hospital Zhangzhou Fu
Foshan Fifth People's Hospital Foshan Guangdong
Foshan Nanhai District Sixth People's Hospital Foshan Guangdong
Brain Hospital Affiliated to Guangzhou Medical University Guangzhou Guangdong
Longchuan Hospital of Traditional Chinese Medicine Heyuan Guangdong
Hospital 925, Joint Logistics Support Force Guizhou Guiyang
Cangzhou People's Hospital of integrated Chinese and Western Medicine, Hebei Province Cangzhou Hebei
Army Military Medical University Officer School affiliated hospital Shijiazhuang Hebei
Tangshan Workers' Hospital Tangshan Hebei
Ningjin County Hospital Xingtai Hebei
Gongyi Xinhua Hospital of Traditional Chinese Medicine Gongyi Henan
Tongxu First Hospital Kaifeng Henan
Fangcheng County People's Hospital Nanyang Henan
Nanyang City Center Hospital Nanyang Henan
Shangqiu First People's Hospital Shangqiu Henan
Yongcheng Central Hospital Shangqiu Henan
The First Affiliated Hospital of Xinxiang Medical College Xinxiang Henan
The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan
Henan Provincial People's Hospital Zhengzhou Henan
The First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou Henan
Zhengzhou First People's Hospital Zhengzhou Henan
Zhengzhou Zhongkang Hospital Zhengzhou Henan
Zhongmou County People's Hospital Zhengzhou Henan
Xihua County People's Hospital Zhoukou Henan
Lichuan Ethnic Chinese Medicine Hospital Lichuan Hubei
Hubei Third People's Hospital Wuhan Hubei
Yueyang City People's Court Yueyang Hubei
Liuyang City Jili Hospital Guankou Hunan
Xiangtan Central Hospital Xiangtan Hunan
Jiujiang First People's Hospital Jiujiang Jiangxi
Jilin City People's Hospital Jilin City Jilin
Xinmin People's Hospital Shenyang Liaoning
Affiliated Hospital of Inner Mongolia University for Nationalities Tongliao Neimenggu

+ 18 more sites — see the full list on the official registry below.

More Capital Medical University trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06615726 on ClinicalTrials.gov ↗ ← All trials in China