Predisposing and precipitating factors for perioperative delirium for the elderly remain elusive. This research will be conducted to determine risk factors of postoperative delirium.
Eligibility
Sex
ALL
Min age
65 Years
Max age
90 Years
Healthy volunteers
No
Inclusion Criteria:
1. 65 to 90 years old to receive elective major abdominal surgery (expected operation time over 2 hours); ,
2. American society of Aneshesiologists（ASA）physical status I-III;
Exclusion Criteria:
1. Mini-Mental State Examination (MMES) score \< 15;
2. Renal failure (requiring dialysis) or liver failure (Child-Pugh score \> 5);
3. Severe impairment due to structural or hypoxic brain injury, more than 2 days in ICU one month before surgery;
4. Underwent major heart, lung or abdominal surgery within 1 year;
5. Positive for Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or symptomatic (e.g. fever, cough, loss of taste/smell);
6. The cognitive assessment cannot be completed because the subject is blind, deaf, or unable to communicate in the local language;
7. Long-term follow-up unavailable (homelessness, active psychosis or substance abuse).
Primary outcome measure(s)
Incidence of delirium during first 7 days after surgery — Consecutive 7 days after the surgery or hospital discharge, whichever comes first. The result of 3-minute Diagnostic Interview for Confusion Assessment Method (3D-CAM) is positive.
Trial sites (1)
Facility
City
Region
Status
The Sixth Affiliated Hospital of Sun Yet-set University
Guangzhou
Guangdong
Recruiting
More Sixth Affiliated Hospital, Sun Yat-sen University trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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