Transcranial Alternating Current StimulationNon-suicidal Self-injury
Investigational drug(s) / intervention(s)
High-Definition Transcranial Alternating Current Stimulation (HD-tACS)sham High-Definition Transcranial Alternating Current Stimulation (HD-tACS)
High-Definition Transcranial Alternating Current Stimulation (HD-tACS): tACS is described as a non-invasive form of brain stimulation that uses a low-intensity, alternating current applied directly to the head through scalp electrodes.
sham High-Definition Transcranial Alternating Current Stimulation (HD-tACS): In the sham condition, tACS was delivered only during the ramp-up and ramp-down periods (15s and 15s); no current was delivered during the 20-minute intervention.
Study summary
To investigate the intervention effect of high-definition transcranial alternating current stimulation (HD-tACS) on patients with Non-suicidal Self-injury (NSSI) and its underlying neural mechanism by magnetic resonance imaging (MRI).
Eligibility
Sex
ALL
Min age
12 Years
Max age
18 Years
Healthy volunteers
No
Inclusion Criteria:
The patients were diagnosed by 2 or more senior clinical psychiatrists, meeting DSM-V criteria, and having 1 or more non-suicidal self-injurious behaviors in the last 6 months.
12-18 years of age.
The medicine has not changed in the 4 weeks prior to or after this study, and if it has to be changed, the treatment medication is required to be at a subtherapeutic dosage level.
Exclusion Criteria:
The patient has suicidal ideation or has committed suicidal behavior
T1 or T2 weighted phase magnetic resonance images show focal brain lesions
patients had neurological disorders such as epilepsy, or serious physical illnesses
patients had a history of substance abuse and drug dependence in the last 6 months or use of anticonvulsant drugs in the last 3 months
patients had received radial cranial electrical stimulation or magnetic stimulation treatment in the last 3 months or received electroconvulsive therapy in the last 6 months
patients had previous significant head trauma or EEG abnormality in the last 1 month
body-mounted devices unsuitable for treatment, such as pacemakers, artificial valves, and other metal implants.
Primary outcome measure(s)
Changes in the number, frequency, and impulsivity of self-injurious behaviors — baseline and immediately after the intervention Adolescent Non-suicidal self-injury Assessment Questionnaire consisted of 2 dimensions and 12 items, with 5 options for each item, namely, "none, occasional, sometimes, often, and always", and was scored on a 5-point Likert scale from 0 to 4. The score for each item was summed up as the total score of the questionnaire, and the total mean score was divided by the number of items. The total mean score was divided by the number of items, and the higher the total mean score, the more serious the patients' non-suicidal Likert 5 self-injurious behaviors were.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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