Second Affiliated Hospital, Zhejiang University, School of Medicine
Phase
Not applicable
Started
2023-06-15
Last updated
2026-08-05
Condition(s) studied
Alveolar Bone Resorption
Investigational drug(s) / intervention(s)
alveolar ridge preservation with bio-oss collagenalveolar ridge preservation with sticky bone
alveolar ridge preservation with bio-oss collagen: Alveolar ridge preservation with bio-oss collagen is a surgical method that reduces or limits the physiological resorption of alveolar bone after tooth extraction by implanting bio-oss collagen in the socket and covering the biological barrier membrane.
alveolar ridge preservation with sticky bone: Alveolar ridge preservation with sticky bone is a surgical method that reduces or limits the physiological resorption of alveolar bone after tooth extraction by implanting sticky bone in the socket and covering the biological barrier membrane.
Study summary
In this experiment, after non-traumatic tooth extraction, the blank group underwent natural healing, and the Bio-Oss Collagen underwent alveolar ridge preservation using Bio-Oss Collagen and the Sticky Bone group using Sticky Bone, to verify the application of Bio-Oss Collagen and Sticky Bone in alveolar ridge preservation
Eligibility
Sex
ALL
Min age
18 Years
Max age
70 Years
Healthy volunteers
Accepted
Inclusion Criteria:
1. The presence of one adjacent tooth at the extraction site
2. Adequate oral hygiene (plaque index \<20%;bleeding on probing \<25% )
3. Need for tooth extraction due to endodontic，periapical or periodontal disease.
4. Presence of ≥ 2 mm of keratinized tissue
5. the extraction sockets have no more than 50% of buccal alveolar bone loss(Integrity of alveolar bone walls)
Exclusion Criteria:
1. Pregnancy or lactation
2. Smoking more than 10 cigarettes per day
3. with no evidence of acute infection such as severe swelling, suppuration at the extraction site
4. Uncontrolled periodontal disease
5. Existence of bone metabolic disease
6. history of malignancy, radiotherapy, or chemotherapy in the past 5 years
7. Administration of bisphosphonates
8. long-term use of NSAIDs
9. Alcohol or drug abuse
10. Infectious disease, such as hepatitis or human immunodeficiency virus (HIV) and/or acquired immunodeficiency syndrome (AIDS)
11. Uncontrolled severe diabetes.( hemoglobin A1c \>6.7%)
Primary outcome measure(s)
Changes in horizontal ridge widths — baseline (before the surgery) and six months Changes in horizontal ridge widths at 1, 3, and 5 mm below the ridge crest
Trial sites (1)
Facility
City
Region
Status
2nd Affiliated Hospital, School of Medicine, Zhejiang University, China
Hangzhou
Zhejiang
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