Interstitial Lung Disease and Obstructive Sleep Apnea

NCT05838183 · tracked via the Priya Life Science China tracker

Sponsor

Dan Liu

Phase

Observational

Started

2019-09-01

Last updated

2026-02-10

Condition(s) studied

ILD OSA

Investigational drug(s) / intervention(s)

The relationship between imaging and ROSE and NGS

The relationship between imaging and ROSE and NGS: The correlation between ROSE and NGS in imaging and bronchoscopy of ILD patients was observed

Study summary

Clinically, all patients with interstitial lung disease(ILD) were observed, and relevant clinical data were collected. Bronchoscopic specimens were collected according to the condition of the enrolled patients, and the rapid on site evaluation(ROSE) was evaluated, combined with the metagenomic next generation sequencing(mNGS) results of these patients. To observe the etiology and biological characteristics of exacerbation in patients with interstitial lung disease.

All patients undergo polysomnography (PSG) and drug-induced sleep endoscopy(DISE). The biological specimens was obtained for molecular biology or other tests.We detected ZNF331, Claudin1, Claudin2, Claudin3, Claudin4, and IL22 as biomarkers to differentiate the diagnostic efficiency of OSA in ILD, ILD+OSA, OSA, and Ctrl groups, respectively

Eligibility

Sex

ALL

Min age

18 Years

Max age

80 Years

Healthy volunteers

Inclusion criteria: * over 18 years old and under 80 years old. * Clinical diagnosis of interstitial lung disease or obstructive respiratory sleep apnea syndrome. * Patient is conscious and capable of signing informed consent. * The patient may wear a polysomnograph. Exclusion criteria: * malignant tumors. * severe heart failure. * uremia. * autoimmune diseases. * pulmonary embolism, and end-stage chronic obstructive pulmonary disease. * Patients with mental illnesscannot sign informed consent on their own.

Primary outcome measure(s)

imaging changes and ROSE and NGS in patients — 2Day
Relationship between imaging changes and ROSE and NGS in patients with interstitial lung disease

Trial sites (1)

Facility	City	Region	Status
Tianjin Medical University General Hospital	Tianjin	China	Recruiting

More Dan Liu trials in China

Combination of Remimazolam and Propofol During Drug-induced Sleep Endoscopy Active, not recruiting

Diagnosis and Comprehensive Treatment of Mediastinal Interventional Technique Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05838183 on ClinicalTrials.gov ↗ ← All trials in China