Functional ComprEhensive AssessmenT by IVUS Reconstruction in Patients With Suspected IschEmic Heart Disease (FEATURE)

Inclusion Criteria: * Subject must be ≥ 18 years * Patients suspected with ischemic heart disease * ≥ 1 diseased vessel with angiographic percent diameter stenosis between 40% and 80% in a vessel ≥ 2.5mm by visual estimation * Target vessels are limited to major epicardial coronary arteries (left anterior descending artery \[LAD\], left circumflex artery \[LCX\], right coronary artery \[RCA\]) Exclusion Criteria: * Patients with previous coronary artery bypass grafting (CABG) * Myocardial infarction within 72h of coronary angiography * Allergy to the contrast agent or adenosine * Left main coronary artery stenosis ≥ 50% * Target vessel with in-stent restenosis * Target vessel with severe tortuosity or angulation * 100% occlusion of target vessel * Target vessel spasm or injury * Target vessel with severe myocardial bridge * Target vessel with severe thrombosis * Intravascular ultrasound (IVUS) pullback fails to cover the complete target lesion * Presence of false lumen at target vessel based on IVUS * A serum creatinine level \>150 umol/l, or a glomerular filtration rate \< 45 ml/kg/1.73 m\^2 * Heart failure * Ineligible for diagnostic intervention (IVUS or FFR examination)