A Study of Brentuximab Vedotin in Combination With Cyclophosphamide, Doxorubicin (Hydroxydaunorubicin), Prednisone (CHP) in Chinese Participants With CD30-Positive (CD30+) Peripheral T-Cell Lymphomas (PTCL)
Brentuximab Vedotin: Brentuximab vedotin IV infusion
Cyclophosphamide: Cyclophosphamide IV infusion
Doxorubicin: Doxorubicin IV infusion
Prednisone: Prednisone tablets
Study summary
This study will use a combination of Brentuximab vedotin with CHP to treat adult Chinese participants with CD30+ PTCL.
The main aims of the study are to evaluate:
* Side effect from the A+CHP
* Check how much A+CHP stays in their blood over time. This will help Takeda to work out the best dose to give people in the future.
* If A+CHP improves outcome of newly diagnosed CD30+ PTCL
Brentuximab vedotin will be given through vein on Day 1 of each 21-day cycle. Cyclophosphamide and doxorubicin will be given through vein. Prednisone will be given orally daily on Days 1 through 5.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
1. Participants must have newly diagnosed CD30+ PTCL, per the Revised European American Lymphoma 2016 World Health Organization (WHO) classification, by local assessment. Tumor specimen must be submitted before enrollment for subsequent central pathology review to confirm histology (and anaplastic lymphoma kinase (ALK) status, if applicable), and CD30 expression. Eligible histologies include:
1. ALK-positive systemic anaplastic large cell lymphoma (sALCL) with an International Prognostic Index (IPI) score of ≥2.
2. ALK-negative sALCL.
3. PTCL- not otherwise specified (NOS).
4. Angioimmunoblastic T-cell lymphoma (AITL).
5. Enteropathy associated T-cell lymphoma (EATL).
6. Hepatosplenic T-cell lymphoma (HSTCL).
2. Eastern Cooperative Oncology Group (ECOG) performance status of less than or equal to 2.
3. Fluorodeoxyglucose (FDG)-avid disease by positron emission tomography (PET) imaging and measurable disease with at least 1 bidimensionally measurable lesion (\>1.5 cm in its largest dimension) by computed tomography (CT).
4. Suitable venous access for the study-required blood sampling, including pharmacokinetic (PK) and immunogenicity sampling.
5. Clinical laboratory values as specified below at screening/baseline within 7 days before the first dose of study drug:
1. Total bilirubin must be ≤1.5 times the upper limit of normal (ULN) or ≤3 times the ULN for participants with Gilbert's disease or documented hepatic involvement with lymphoma.
2. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) must be ≤3 times the ULN or ≤5 times the ULN for participants with an elevation that can be reasonably ascribed to the presence of metastatic disease in liver.
3. Serum creatinine must be \<2.0 milligram per deciliter (mg/dL) and/or creatinine clearance or calculated creatinine clearance \>40 milliliter (mL)/minute.
4. Hemoglobin must be ≥8 grams per deciliter (g/dL). (Red blood cell transfusion is allowed ≥14 days before assessment.)
5. Absolute neutrophil count \>1.5×10\^9/liter (L).
6. Platelet count ≥75×10\^9/L (unless documented bone marrow involvement with lymphoma).
Exclusion Criteria:
1. Systemic anticancer therapy, including traditional Chinese medicine with antitumor indication for disease under study before the first dose of study drugs.
2. Major surgery within 28 days before the first dose of study drug.
3. Known human immunodeficiency virus (HIV)-positive status.
4. Known hepatitis B virus (HBV) surface antigen (HBsAg) seropositivity or active hepatitis C virus infection.
Note: Participants who have positive HBV core antibody and are HBsAg negative can be enrolled, but must have an undetectable HBV viral load.
5. Diagnosed or treated for another malignancy within 3 years before the first dose or previously diagnosed with another malignancy and have any evidence of residual disease. Participants with nonmelanoma skin cancer or carcinoma in situ of any type are not excluded if they have undergone complete resection.
6. Any of the following cardiovascular conditions or values within 6 months before the first dose of study drug:
1. Left-ventricular ejection fraction \<45%.
2. Myocardial infarction within 6 months of enrollment.
3. New York Heart Association Class III or IV heart failure.
7. Participants with current diagnosis of primary cutaneous CD30+ T-cell lymphoproliferative disorders and lymphomas. Participants with cutaneous anaplastic large cell lymphoma (ALCL) with extracutaneous tumor spread beyond locoregional lymph nodes are eligible (previous single-agent treatment to address cutaneous and locoregional disease is permissible).
8. Participants with mycosis fungoides (MF) \[including transformed MF\].
9. Uncontrolled diabetes mellitus.
10. Baseline peripheral neuropathy ≥Grade 2 (National Cancer Institute Common Terminology Criteria for Adverse Events \[NCI CTCAE\], version 5.0).
11. History of progressive multifocal leukoencephalopathy (PML).
12. Previous treatment with brentuximab vedotin or CD30 monoclonal antibody.
Primary outcome measure(s)
Overall Response Rate (ORR) by Independent Review Facility (IRF) Assessment Per Revised Response Criteria for Malignant Lymphoma — Up to approximately 7 months ORR by IRF assessment following the completion of study treatment was defined as the percentage of participants who achieved a complete response (CR) or partial response (PR) by IRF assessment using the International Working Group (IWG) Revised Response criteria following the completion of study treatment. CR was defined as disappearance of all evidence of disease. PR was defined as regression of measurable disease and no new sites.
Percentage of Participants Who Experienced at Least One Treatment Emergent Adverse Event (TEAE) — Up to approximately 7 months An adverse event (AE) is defined as any untoward medical occurrence in a participant administered a pharmaceutical product; it does not necessarily have to have a causal relationship with this treatment. An AE can therefore be any unfavorable and unintended sign (e.g., a clinically significant abnormal laboratory finding), symptom, or disease temporally associated with the use of a drug, whether or not it is considered related to the drug. A TEAE is defined as an adverse event that occurs after administration of the first dose of study treatment and up through 30 days after the last dose of study treatment.
Number of Participants With Abnormal Changes From Baseline in Laboratory Measurements — Up to approximately 7 months Laboratory parameters like Potassium, Aspartate Aminotransferase (AST), Bilirubin, Serum Gamma-glutamyl Transferase (GGT), High Glucose (Hyperglycemia), Neutrophils, Leukocytes, Platelets, and Hemoglobin were assessed.
Intensity of changes in laboratory parameters were evaluated using the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.
Number of Participants With Abnormal Changes From Baseline in Vital Sign Measurements (Blood Pressure) — Up to approximately 7 months
Trial sites (16)
Facility
City
Region
Status
Beijing Cancer Hospital
Beijing
China
Peking University Third Hospital
Beijing
China
The First Hospital of Jilin University
Changchun
China
West China Hospital, Sichuan University
Chengdu
China
Chongqing University Cancer Hospital
Chongqing
China
Fujian Medical University Union Hospital
Fuzhou
China
Guangdong Provincial Peoples Hospital
Guangzhou
China
The First Affiliated Hospital of Zhejiang University school of medicine
Hangzhou
China
Anhui Provincial Cancer Hospital
Hefei
China
Shandong Cancer Hospital
Jinan
China
The First Affiliated Hospital of Nanchang University
Nanchang
China
Fudan University Shanghai Cancer Center
Shanghai
China
Shengjing Hospital of China Medical University
Shenyang
China
The First Affiliated Hospital of Soochow University
Suzhou
China
Tianjin Medical University Cancer Institute & Hospital
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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