Prediction of Development and Rupture Risk for Intracranial Unruptured Aneurysms

Condition(s) studied

Investigational drug(s) / intervention(s)

Unruptured intracranial aneurysms: Extensive clinical, biological and imaging data of unruptured intracranial aneurysm patients will be recorded during a 5 years follow-up.

Study summary

In recent years, researches on the natural history and risk factors of intracranial unruptured aneurysms have become a hot topic at home and abroad. However, risk factors for aneurysm rupture is still unclear yet. The investigators' preliminary study focused on constructing a rupture risk prediction system for intracranial unruptured aneurysm in the investigators' single center. The investigators' result showed that three significant factors (sex, abnormal serum tumor necrosis factor (TNF)-α and coincidence of thin-walled regions (TWR) and normalized wall shear stress (NWSS)) stood out by using logistic regression to explore the rupture risk factors of intracranial unruptured aneurysms, which could help guide the clinical treatment of intracranial unruptured aneurysms. This study is to evaluate and improve the rupture predict model of intracranial unruptured aneurysm in multi-neurosurgical centers.

Eligibility

Primary outcome measure(s)

• Predictive value of coincidence of TWR and NWSS for unruptured aneurysm rupture — at 5 year
  at 5 years, the value of the factor (coincidence of TWR and NWSS) to predict aneurysm rupture risk will be analyzed
• Predictive value of serum TNF-α for unruptured aneurysm rupture — at 5 year
  at 5 years, the value of the factor (serum TNF-α) to predict aneurysm rupture risk will be analyzed
• Predictive value of sex for unruptured aneurysm rupture — at 5 year
  at 5 years, the value of the factor (sex) to predict aneurysm rupture risk will be analyzed

Trial sites (1)

More Second Affiliated Hospital, Zhejiang University, School of Medicine trials in China

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