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Clinical Trials in China / NCT05503667
Recruiting Phase 2

Neoadjuvant Furmonertinib Plus Bevacizumab or Furmonertinib Monotherapy for Resectable and Potentially Resectable Stage III-IVA EGFR Mutation-Positive Lung Adenocarcinoma

NCT05503667 · tracked via the Priya Life Science China tracker
Sponsor
Shanghai Pulmonary Hospital, Shanghai, China
Phase
Phase 2
Started
2022-02-01
Last updated
2022-08-17

Condition(s) studied

Lung Adenocarcinoma Stage IIILung Adenocarcinoma Stage IVEGFR Gene Mutation

Investigational drug(s) / intervention(s)

Furmonertinib →Bevacizumab →

Furmonertinib: Furmonertinib 80 mg/day for 16 weeks

Bevacizumab: bevacizumab 400 mg/4 weeks i.v. for 4 times

Study summary

To explore the efficacy and safety of neoadjuvant furmonertinib combined with bevacizumab in the treatment of resectable and potentially resectable stage III-IVA EGFR mutation-positive lung adenocarcinoma.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Lung adenocarcinoma patient with EGFR sensitive mutation as confirmed by needle biopsy; * At stage III-IVA (TNM Staging, Version 8) as identified by chest CT, PET-CT or/and EBUS; * No systemic metastasis (confirmed by head MRI, whole body bone scan, PET-CT, liver and adrenal CT, etc.); * With the feasiblility or potential feasibility to receive radical surgery (radical lung lobectomy+systematic lymph node dissection); * Good lung function that could tolerate surgical treatment; * Aged \>= 18 years; * At least one measurable tumor foci (the longest diameter measured by CT shall be \> 10 mm); * Other major organs shall function well (liver, kidney, blood system, etc.): * ECOG PS score shall be 0-1; * The child-bearing female must undergo pregnancy test within 7 days before starting the treatment and the result shall be negative. Reliable contraceptive measures, such as intrauterine device, contraceptive pill and condom, shall be adopted during the trial and within 30 days after completion of the trial. The child-bearing male shall use condom for contraception during the trial and within 30 days after completion of the trial; * The patient shall sign the Informed Consent Form. Exclusion Criteria: * The patient has undergone any systemic anti-cancer treatment for NSCLC, including cytotoxic drug treatment, targeted drug treatment and experimental treatment, etc.; * The patient suffers from any unstable systemic disease (including active infection, uncontrolled hypertension, unstable angina pectoris, angina pectoris that starts to attack within the last 3 months, congestive heart failure \[≥ Grade II specified by New York Heart Association (NYHA)\], cardiac infarction (6 months before enrollment), severe arrhythmia and liver, kidney or metabolic diseases that requires drug treatment; * The patient is a carrier of HIV; * The patient is currently suffering from interstitial lung disease; * The patient had undergone other major systemic operations or suffered from severe trauma within 3 months before the trial; * The patient is allergic to furmonertinib or its any excipients; * The patient is allergic to bevacizumab or its any excipients; * The female patient is in pregnancy or lactation period; * There are any conditions under which the investigator considers the patient is not suitable to be enrolled.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Shanghai Pulmonary Hospital Shanghai Shanghai Municipality Recruiting

On this site

📄 Avastin (bevacizumab) drug profile →

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05503667 on ClinicalTrials.gov ↗ ← All trials in China