Performances on Cognitive Functions and Brain Function and Follow-up After Different Treatments in Patients With Autonomous Cortisol Secretion: a Single-center, Prospective, Observational Study
Cognitive function assessment; functional magnetic resonance imaginglaparoscopic adrenal surgery
Cognitive function assessment; functional magnetic resonance imaging: cognitive function measurement
laparoscopic adrenal surgery: Only a subgroup of the autonomous cortisol secretion patients will have the laparoscopic adrenal surgery
Study summary
This is a single center, prospective, observational study to explore and evaluate the differences on cognitive function and brain function by functional-MRI in autonomous cortisol secretion patients, and the different treatments methods on the cognitive function and brain function in patients with autonomous cortisol secretion
Eligibility
Sex
ALL
Min age
20 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* age 20-65 years;
* ≥ 6 years of education；
* right-handed;
* complete entire cognitive function tests;
* adrenal lesions ≥ 1 cm in diameter;
* patients with non-functioning adrenal adenomas;
* patients with autonomous cortisol secretion.
Exclusion Criteria:
* \< 6 years of education;
* age \< 20 years or \> 65 years;
* maximum diameter of AI \<1cm;
* active malignancies;
* with a history of thyroid disease;
* with a history of acute infection in the last month;
* central nervous system diseases, including brain trauma, intracranial hemorrhage, acute cerebral infarction, etc;
* contraindications of MRI examination: such as implantation of metal prosthesis in vivo, claustrophobia, etc;
* adrenal tuberculosis;
* suspected or diagnosed adrenocortical carcinoma;
* unable to complete entire cognitive function tests;
* current use of steroids or any drugs known to alter steroid synthesis or metabolism in the previous 3 months;
* clinical Cushing syndrome;
* Cushing disease;
* primary hyperaldosteronism;
* pheochromocytoma;
* severe impairment of heart, liver, kidney and other organs;
* pregnant and lactating women
Primary outcome measure(s)
Participants' personal information — 1 day Self-reported information(education in years)
Physical assessments — 1 day BMI(body mess index) in kg/m\^2
Imaging examinations — 1 day Adrenal adenoma size in cm
Montreal Cognitive Assessment (MoCA) — 20 minutes The MoCA is a Global cognitive screening test designed to assist Health Professionals in detection of mild cognitive impairment.
Mini-Mental State Examination (MMSE) — 20 minutes The MMSE is a cognitive screening test designed to assist Health Professionals in detection of mild cognitive impairment.
Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) — 1 hour The RBANS is a cognitive screening test designed to assist Health Professionals in evaluation of multiple cognitive subdomains
Rest Functional MRI of the brain function. — 40 minutes Rs-fMRI
Screening for adrenal cortisol hypersecretion — 1 day Patients were given 1 mg dexamethasone orally at 24:00 am, and the cortisol levels were measured at 8:00 am the following morning
Trial sites (1)
Facility
City
Region
Status
Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School
Nanjing
Jiangsu
Recruiting
More The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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