Clinical Registration Study of Patients With Intracranial / Carotid Stenosis

NCT05322824 · tracked via the Priya Life Science China tracker

Sponsor

Second Affiliated Hospital, Zhejiang University, School of Medicine

Phase

Observational

Started

2022-01-01

Last updated

2023-04-18

Condition(s) studied

Cognitive FunctionStenosis

Investigational drug(s) / intervention(s)

standard medical treatmentInterventional stenting

standard medical treatment: standard medical treatment

Interventional stenting: Interventional stenting

Study summary

Through prospective registration and follow-up, this study will collect data of patients with intracranial/carotid stenosis, including clinical information, neuropsychological scales, multimodal magnetic resonance images. The investigators aim to analyze clinical and imaging characteristics of patients with cognitive impairment related to intracranial/carotid stenosis, in order to achieve early identification of cognitive impairment.

Eligibility

Sex

ALL

Min age

40 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Patients aged ≥ 40 years * ≥ 50% stenosis in unilateral intracranial / carotid artery * Written informed consent available Exclusion Criteria: * Previous history of major head trauma and any intracranial surgery * Intracranial abnormalities, such as intracerebral hemorrhage, subarachnoid hemorrhage and other space occupying lesions * Extrapyramidal symptoms or mental illness which may affect neuropsychological measurement * Severe loss of vision, hearing, or communicative ability Exit Criteria: * Not meet the inclusion criteria * For any poor adherence, not comply with the requirements of the follow-up, or safety reasons determined by investigator * Any adverse or serious adverse events during the study period judged by investigator

Primary outcome measure(s)

Changes in the scores of Mini-mental State Examination — 2 years
Total score of 30. Higher scores mean a better outcome.

Trial sites (1)

Facility	City	Region	Status
Second Affilated Hospital of Zhejiang University, School of Medicine	Hangzhou	Zhejiang	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05322824 on ClinicalTrials.gov ↗ ← All trials in China