propofol: General anesthesia is induced and maintained mainly with propofol.
sevoflurane: General anesthesia is induced and maintained mainly with sevoflurane.
S-ketamine: General anesthesia is induced mainly with S-ketamine and maintained mainly with propofol.
Study summary
The change profiles of indices derived from pEEG such as phase-amplitude coupling and bicoherence based on individual general anesthetics in children have not been examined in previous literature. Whether those indices have the abilities to predict individual drug-related anesthesia depth in children need to be explored.
Eligibility
Sex
ALL
Min age
1 Minute
Max age
18 Years
Healthy volunteers
No
Inclusion Criteria:
* patients aged 0-18 years, American Society of Anesthesiologists Physical Status I-II, scheduled for elective surgery in Peking University First Hospital.
Exclusion Criteria:
* Preterm patients;
* Height and weight not within the standard ranges for respective ages;
* Surgery for head or heart;
* Patients with muscular, neurologic or psychiatric diseases;
* Patients with Congenital anomaly or hereditary diseases;
* Patients with medication abuse;
* Allergy to medication including propofol, sevoflurane, and ketamine;
* Allergy to beans;
* Refusal to participate the study by guardians.
Primary outcome measure(s)
phase-amplitude coupling — induction, maintenance, and recovery of anesthesia phase-amplitude coupling
bicoherence — induction and maintenance, and recovery of anesthesia bicoherence
spectral analysis — induction and maintenance, and recovery of anesthesia spectral analysis
entropy indices — induction and maintenance, and recovery of anesthesia entropy indices
Trial sites (1)
Facility
City
Region
Status
Peking University First Hospital
Beijing
China
Recruiting
More Peking University First Hospital trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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