PSMA PET: PSMA PET may have influence on the clinical decision-making of the patients with renal cancer
Study summary
The primary research purpose is to evaluate the diagnostic efficacy of 68Ga-PSMA PET in metastatic lesions of locally advanced and advanced renal cell carcinoma, and to compare with that of enhanced CT. The second purpose is to evaluate whether 68Ga-PSMA PET can change the treatment decision of patients with locally advanced and advanced renal cell carcinoma
Eligibility
Sex
ALL
Min age
18 Years
Max age
90 Years
Healthy volunteers
No
Inclusion Criteria:
* 2017 AJCC renal cell carcinoma TNM stage III, IV lesions;
* In contrast-enhanced CT staging, suspicious metastases were found;
* There were no known peripheral or central venous problems;
* 68Ga PSMA PET / CT imaging can be performed within 6 weeks after the diagnosis of renal cell carcinoma;
* Signed the informed consent form of voluntary participation in clinical trials.
Exclusion Criteria:
* Age ≤ 18 years old;
* Can't stand lying flat in PET / CT examination;
* There are contraindications for 68Ga PSMA ligands;
* In the past two years, there was a history of other malignant tumors, or according to the doctor's research judgment, complications may occur and affect the normal operation of the test;
* Renal function is impaired or hemodialysis is in progress.
Primary outcome measure(s)
Additional diagnostic value of 68Ga PSMA PET / CT compared with CT in patients with locally advanced and advanced renal cell carcinoma — 2 years The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of 68Ga-PSMA PET/CT compared with enhanced CT in diagnosing locally advanced and advanced renal cell carcinoma metastases in clinical practice. If the diagnostic performance of 68Ga PSMA PET / CT is better than enhanced CT, it may have additional diagnostic value in in locally advanced and advanced renal cell carcinoma.
Trial sites (9)
Facility
City
Region
Status
The First Hospital of Lanzhou University
Lanzhou
Gansu
Recruiting
General Hospital of Ningxia Medical University
Yinchuan
Ningxia
Recruiting
Qinghai University Affiliated Hospital
Xining
Qinghai
Recruiting
Xijing Hospital
Xi'an
Shaan'xi
Recruiting
Weinan Central Hospital
Weinan
Shaanxi
Recruiting
Shaanxi Provincial People's Hospital
Xi'an
Shaanxi
Recruiting
Xijing 986 Hospital
Xi'an
Shaanxi
Recruiting
The Second Affiliated Hospital of Shaanxi University of Chinese Medicine
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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