99Tc-MDP Treatment for Knee Osteoarthritis

NCT02993029 · tracked via the Priya Life Science China tracker

Sponsor

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Phase

Not applicable

Started

2017-09-01

Last updated

2026-04-28

Condition(s) studied

Treatment Outcome

Investigational drug(s) / intervention(s)

99Tc-MDPCelecoxib

99Tc-MDP: 99Tc-MDP 15mg in 100ml normal saline intravenously dripped every twice a week for 5 weeks, every 1weeks for 10 weeks, every 2weeks for 10 weeks, every 1 month for 6 months.

Celecoxib: Celecoxib capsule 200mg qd by mouth.

Study summary

Osteoarthritis (OA) of knee is the most common form of arthritis in the world1e, and it has received growing attention in the society because of the increase of old age population, disabled people, and medical expenses from this disease. 99Tc-MDP is effective for rheumatoid arthritis. Therefore, the investigators try to investigate the effects of 99Tc-MDP treatment in patients with osteoarthritis of knee as compared with celecoxib.

Eligibility

Sex

ALL

Min age

40 Years

Max age

—

Healthy volunteers

Inclusion Criteria: 1. Participants with painful osteoarthritis; 2. The standard uptake value (SUV) of OA related knee greater than 10 on 18F- sodium fluoride bone scan; 3. Participants voluntarily participate in the trial, and signed the informed consent. Exclusion Criteria: 1. Knee joint replacement; 2. Inflammatory arthritis or joint infection of knee; 3. Nervous joint disease; 4. Fracture of joint; 5. Gout arthritis of the knee; 6. Traumatic arthritis.

Primary outcome measure(s)

pain, stiffness and joint function of knee — baseline, and 6, 12 months after treatment.
change of the pain, stiffness and joint function of knee (mean and standard deviation) by Western Ontario and McMaster Universities (WOMAC)Osteoarthritis Index

Trial sites (1)

Facility	City	Region	Status
Department of Nuclear Medicine, Tenth People's Hospital of Tongji University	Shanghai	Shanghai Municipality	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT02993029 on ClinicalTrials.gov ↗ ← All trials in China