Partial sleep deprivation: Participants will be asked to come to the lab for testing after a night of partial sleep deprivation. Participants will be asked to fall asleep at their habitual bedtime but wake up early (\~40% of normal sleep duration).
Study summary
The goal of this clinical trial is to determine if attenuations in cardiac output drive the blunted blood pressure response during cycling exercise following a night of partial sleep deprivation in young healthy adults (%50 females). The secondary outcome is to assess sex differences. The main questions it aims to answer are:
* Do reductions in plasma volume drive reductions in cardiac output and therefore blood pressure during exercise following a night of partial sleep deprivation?
* Do sex differences exist?
Participants will:
* Visit the lab after a night of normal sleep and a night of partial sleep deprivation.
* Keep a daily diary of their sleep and food/beverage intake.
* Perform maximal and submaximal exercise on a cycle ergometer.
Eligibility
Sex
ALL
Min age
18 Years
Max age
50 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Free of known cardiovascular or metabolic diseases or sleep disorders
* No history of smoking (within the past 3 months)
* Able to engage in physical activity assessed through the physical activity readiness questionnaire (PAR-Q+)
* No prescription of chronic medications other than oral contraceptives
* Able to abide by sleep protocols for all visits
* Individuals who are not allergic to ultrasound gel
* Individuals who are not pregnant
Exclusion Criteria:
* Individuals diagnosed with cardiovascular or metabolic disease or sleep disorders
* Has a history of smoking (within the past 3 months)
* Not ready to engage in physical activity as assessed by the PAR-Q+
* Individuals prescribed chronic medications other than oral contraceptives
* Unable to abide by sleep protocols for any testing visit
* Allergic to ultrasound gel
* Pregnancy
Primary outcome measure(s)
cardiac output responses to cycling exercise — Comparison between normal sleep and partial sleep deprivation, ~3 weeks Cardiac output during exercise after a night of normal sleep and after a night of partial sleep deprivation
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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