12-week precision exercise training: The 12-week exercise intervention will consist of both aerobic and strength exercise training performed 3x per week using an individualized and nonlinear periodized approach.
Study summary
The goal of this interventional clinical research study is to assess the efficacy of a 12-week precision exercise training intervention to improve exercise tolerance in sepsis survivors.
The main question it aims to answer is does a 12-week precision exercise training program improve constant load exercise time in sepsis survivors?
Participants will:
* Answer questionnaires related to patient reported outcomes and give a blood sample
* Perform a constant load exercise test
* Complete 12-weeks (3 x per week, 36 session in total) of precision exercise training consisting of individualized, nonlinear periodized strength and aerobic exercise training.
Researchers will compare the exercise group to an attention control group of sepsis survivors who do not receive exercise training but instead undergo usual care procedures and receive general lifestyle advice 1x per week.
Eligibility
Sex
ALL
Min age
19 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Signed informed consent
* At least 19 years of age
* ≥60 days prior to study enrollment, known or suspected infection that includes at least two of the following clinical criteria that together constitute a new bedside clinical score termed quickSOFA (qSOFA): respiratory rate \>22breaths/min, altered mentation, or systolic blood pressure \<100mmHg.
* Cardiorespiratory fitness \<80% of age and sex-predicted norms
* Can commit to attending 3 exercise sessions a week for 12-weeks
Exclusion Criteria:
* Unable to provide informed consent
* On supplemental oxygen
* Known previous cardiac or cerebral vascular events in the past 90 days
* Diabetes
* Autoimmune diseases or on daily immunomodulatory drugs
* Obstructive sleep apnea
* Uncontrolled hypertension
* Known pregnancy/ intending to get pregnant within 28 days of enrolling in the study or breastfeeding
* Desaturation during exercise SpO2\<85%
* Cardiovascular contraindication or musculoskeletal limitations to exercise as assessed during the cardiopulmonary exercise test
Primary outcome measure(s)
Change in constant load exercise time — 12-weeks Individuals will complete a constant-load exercise trial to symptom limitation at \~70% workload maximum (determined by a cardiopulmonary exercise test) on a cycle ergometer pre to post 12-weeks of the intervention period. The primary outcome will be change in time from pre to post test.
Trial sites (1)
Facility
City
Region
Status
St. Paul's Hospital - Centre for Heart Lung Innovation
Vancouver
British Columbia
Recruiting
More University of British Columbia trials in Canada
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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