Antimicrobial Prophylaxis for Skin Colonization With Propionibacterium Acnes in Primary Open Shoulder Surgery

Condition(s) studied

Investigational drug(s) / intervention(s)

Cefazolin: Antibiotic that will be give before a Trauma or elective open shoulder surgery

Ceftriaxone: Antibiotic that will be give before a Trauma or elective open shoulder surgery

Study summary

INESS Antibiotic Prophylaxis in Orthopedic Guide recommends the use of Cefazolin at induction for all orthopaedic procedure with implantation of internal fixation device. With the increasing rate of identified P. acnes shoulder surgery infection despite the use of recommended skin preparation and preoperative prophylactic antibiotics, a question arises; Is Cefazolin the most effective prophylactic antibiotic for shoulder surgery? The objective of this study is to determine if Ceftriaxone is superior to Cefazolin as a prophylactic antibiotic for skin colonization with P. acnes in primary shoulder surgery

Eligibility

Primary outcome measure(s)

• Skin Biopsy — At the initial surgery
  Number of bacteria identified in five skin biopsies taken at the surgical site

Trial sites (1)

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