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Smith & Nephew clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine — current trials in our USA, UK and China registers with Smith & Nephew as lead sponsor. Synced 26 Sep 2026
19Current trials
7Recruiting now
0Drugs in these trials
3Trial registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from ClinicalTrials.gov and CTIS registry records · Last verified · Editorial standards
At a glance

Smith & Nephew is the lead sponsor of 19 current clinical trials in our USA, UK and China registers. 7 are recruiting patients now. The most common phase is Observational. The most-studied condition is Rotator Cuff Injuries.

Company profile on this site (news, sites, medicines, approvals): Smith & Nephew (GB) →

ClinicalTrials.gov trials by status

  • Recruiting737%
  • Not yet open15%
  • Active, closed947%
  • By invitation211%

Trials by phase

  • Observational1684%
  • Not applicable316%
01

Clinical trials sponsored by Smith & Nephew

19 on ClinicalTrials.gov
StudyPhaseStatusStartRegisters
AETOS Shoulder System
NCT06319911 · Shoulder Osteoarthritis, Shoulder Arthritis
Observational Recruiting 2024-03 USA
Evaluation of Outcomes Following In-office Tympanostomy Using the Tula® System: a Prospective, Multi-center Registry
NCT05915078 · Otitis Media With Effusion, Acute Otitis Media, Otitis Media
Observational Recruiting 2023-06 USA
Use of the REGENETEN™ Bioinductive Implant System in High Grade Partial-thickness Tears
NCT05444465 · ClinicalTrials.gov ↗ · Rotator Cuff Injuries
Not applicable Recruiting 2022-08 UK, USA
Evaluation Of Outcomes Following Rotator Cuff Repair Using the REGENETEN Bioinductive Implant
NCT06857084 · ClinicalTrials.gov ↗ · Rotator Cuff Injuries
Observational Recruiting 2020-10 UK
Post-Market Clinical Study to Evaluate the Safety and Effectiveness of REFLEX ULTRA 45 for Coblation Inferior Turbinate Reduction in China
NCT07025304 · ClinicalTrials.gov ↗ · Nasal Obstruction Due to Inferior Turbinate Hypertrophy
Not applicable Recruiting 2025-07 China
A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)
NCT07199738 · ClinicalTrials.gov ↗ · Inflammatory Arthritis, Primary Total Knee Arthroplasty Due to Degenerative Joint Disease (Primary Diagnosis of Osteoarthritis), Post-traumatic Arthritis
Observational Recruiting 2025-09 USA
Study to Evaluate the Safety and Effectiveness of the REAL INTELLIGENCE™ CORI™ in Total Knee Arthroplasty (TKA) Procedure
NCT04848896 · ClinicalTrials.gov ↗ · Arthroplasty, Replacement, Knee
Not applicable Recruiting 2022-02 China
Knee Cartilage Repair Registry
NCT07786207 · ClinicalTrials.gov ↗ · Knee Injuries, Joint Surface Knee Lesions
Observational Not yet open 2026-09 USA
A Multicenter, Post-Market Clinical Follow-up Study of Subjects With the REDAPT™ System Monolithic Sleeveless/Sleeved Stem and/or Fully Porous Acetabular Shell With XLPE Liner and/or Modular Shell Components Previously Implanted
NCT03610789 · ClinicalTrials.gov ↗ · Hip Replacement
Observational By invitation 2018-05 USA
A Post Approval Multicenter 10 Year Follow-up Observational Trial of Marketed Product - MP01 vs. Surgical Standard of Care (SSOC) Used for the Treatment of Joint Surface Lesions of the Knee
NCT06916728 · ClinicalTrials.gov ↗ · Knee Injuries, Joint Surface Knee Lesions
Observational By invitation 2025-05 USA
A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis
NCT05197036 · Osteoarthritis, Post-traumatic Arthritis, Rheumatoid Arthritis
Observational Active, closed 2021-12 USA
JOURNEY™ II CR Total Knee System
NCT02440672 · ClinicalTrials.gov ↗ · Osteoarthritis, Knee
Observational Active, closed 2015-09 UK, USA
JOURNEY II XR Safety and Effectiveness PMCF
NCT03136887 · ClinicalTrials.gov ↗ · Rheumatoid Vasculitis With Rheumatoid Arthritis of Knee, Unilateral Post-Traumatic Osteoarthritis of Knee, Knee Osteoarthritis
Observational Active, closed 2017-07 USA
A Multi-Centre Study in Patients Undergoing Total Hip Arthroplasty With the Smith+Nephew CATALYSTEM™ Primary Hip System
NCT06564636 · ClinicalTrials.gov ↗ · Total Hip Arthroplasty (THA), Osteoarthritis, Degenerative Joint Disease
Observational Active, closed 2024-09 USA
Safety and Performance Study of the Legion Porous System in Total Knee Arthroplasty
NCT03720782 · ClinicalTrials.gov ↗ · Total Knee Arthroplasty
Observational Active, closed 2019-05 USA
LEGION Hinge Safety and Efficacy Study
NCT02445443 · ClinicalTrials.gov ↗ · Knee Arthroplasty, Total
Observational Active, closed 2015-06 USA
Ten Year Implant Survivorship of the ANTHEM™ PS Total Knee System
NCT03078543 · ClinicalTrials.gov ↗ · Arthroplasty, Replacement, Knee
Observational Active, closed 2017-06 China
Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XLPE High Flex Tibial Inserts
NCT03687593 · ClinicalTrials.gov ↗ · Total Knee Arthroplasty
Observational Active, closed 2018-08 USA
Safety and Effectiveness Study of OR3O™ Dual Mobility System in THA
NCT04325022 · ClinicalTrials.gov ↗ · Advanced Degeneration of the Hip Joint, Revision of the Hip Joint
Observational Active, closed 2020-07 USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Titles and statuses are copied from the registry as published.

02

Conditions in Smith & Nephew trials

30 conditions
Rotator Cuff Injuries2Osteoarthritis2Post-traumatic Arthritis2Knee Injuries2Joint Surface Knee Lesions2Inflammatory Arthritis2Total Knee Arthroplasty2Osteoarthritis, Knee1Shoulder Osteoarthritis1Shoulder Arthritis1Rheumatoid Arthritis1Otitis Media With Effusion1Acute Otitis Media1Otitis Media1Rheumatoid Vasculitis With Rheumatoid Arthritis of Knee1Unilateral Post-Traumatic Osteoarthritis of Knee1Knee Osteoarthritis1Degenerative Arthritis Peripheral Joint1Primary Total Knee Arthroplasty Due to Degenerative Joint Disease (Primary Diagnosis of Osteoarthritis)1Total Hip Arthroplasty (THA)1Degenerative Joint Disease1Hip Replacement1Knee Arthroplasty, Total1Advanced Degeneration of the Hip Joint1
03

By trial register

RegisterTrialsRecruiting
Clinical trials in USA154
Clinical trials in UK32
Clinical trials in China32

A trial with sites in more than one country appears in each of those registers.

04

Questions about Smith & Nephew trials

How many clinical trials does Smith & Nephew sponsor?

Smith & Nephew is the lead sponsor of 19 current trials on ClinicalTrials.gov in our USA, UK and China registers, as of the registry sync on 26 September 2026. Completed and withdrawn studies are not counted.

Are Smith & Nephew trials recruiting?

Yes. 7 of its 19 ClinicalTrials.gov trials are recruiting. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Where does this information come from?

Every trial, status, phase and condition on this page is copied from public ClinicalTrials.gov and EU CTIS records by a daily sync, grouped by the sponsor name each registry records. It says nothing about the organisation beyond its registered trials, and it is not medical advice.

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How this page is built

Everything on this page is copied from public registry records — it is not written from memory, and nothing here describes the organisation beyond its registered trials. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our trial registers and groups every current trial by its lead sponsor name, ignoring legal-form suffixes such as Inc. or Ltd. A small, hand-checked list joins the same organisation's different registry names (for example its EU legal entity). There is no AI drafting and no per-sponsor editorial pass. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The the registries data on this page was last retrieved on 26 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.