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Replimune clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine and the EU Clinical Trials Information System (CTIS) — current trials in our USA, UK and EU (CTIS) registers with Replimune as lead sponsor. Synced 26 Sep 2026
10Current trials
4Recruiting now
10Drugs in these trials
3Trial registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from ClinicalTrials.gov and CTIS registry records · Last verified · Editorial standards
At a glance

Replimune is the lead sponsor of 10 current clinical trials in our USA, UK and EU (CTIS) registers. 4 are recruiting patients now. The most common phase is Phase 2. The drugs named most often in its trials are Nivolumab, RP2 and Ipilimumab. The most-studied condition is Cancer.

ClinicalTrials.gov trials by status

  • Recruiting444%
  • Active, closed556%

Trials by phase

  • Phase 2333%
  • Phase 1222%
  • Phase 3111%
  • Phase 2/3111%
  • Observational111%
  • Phase 1/2111%
01

Clinical trials sponsored by Replimune

9 on ClinicalTrials.gov
StudyPhaseStatusStartRegisters
VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]
NCT06264180 · Advanced Melanoma
Phase 3 Recruiting 2024-07 UK, USA
Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced or Metastatic HCC
NCT05733598 · Hepatocellular Carcinoma, Biliary Tract Cancer
Phase 2 Recruiting 2024-08 USA
A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
NCT06581406 · ClinicalTrials.gov ↗ · Metastatic Uveal Melanoma
Phase 2/3 Recruiting 2024-12 UK, USA
A Study to Assess the Long-term Safety Outcomes in Patients Previously Treated With RP1, RP2, or RP3
NCT06887348 · ClinicalTrials.gov ↗ · Melanoma, Metastatic Melanoma, Advanced Solid Tumor
Observational Recruiting 2025-12 USA
Study of RP2 Monotherapy and RP2 in Combination With Nivolumab in Patients With Solid Tumors
NCT04336241 · Cancer
Drugs: Nivolumab, RP2
Phase 1 Active, closed 2019-10 UK
Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE)
NCT03767348 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer (NSCLC), Microsatellite Instability-High (MSI-H), Non-melanoma Skin Cancer (NMSC)
Drug: Nivolumab
Phase 2 Active, closed 2017-09 UK, USA
Study of RP3 Monotherapy and RP3 in Combination With Nivolumab in Patients With Solid Tumours
NCT04735978 · ClinicalTrials.gov ↗ · Advanced Solid Tumor
Drug: Nivolumab
Phase 1 Active, closed 2020-12 UK, USA
Study Evaluating Cemiplimab Alone and Combined With RP1 in Treating Advanced Squamous Skin Cancer
NCT04050436 · ClinicalTrials.gov ↗ · Cutaneous Squamous Cell Carcinoma, Advanced Cutaneous Squamous Cell Carcinoma, Metastatic Cutaneous Squamous Cell Carcinoma
Phase 2 Active, closed 2019-10 USA
Study to Investigate the Efficacy and Safety of RP1 in Adult Patients With Organ Transplants and Advanced Skin Malignancies
NCT04349436 · ClinicalTrials.gov ↗ · Merkel Cell Carcinoma, Basal Cell Carcinoma, Locally Advanced Cutaneous Squamous Cell Carcinoma
Phase 1/2 Active, closed 2020-05 USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Titles and statuses are copied from the registry as published.

02

Replimune in the EU trials register (CTIS)

1 trial

Authorised or ongoing trials in the EU Clinical Trials Information System with Replimune as sponsor. Some are the same study as a ClinicalTrials.gov record above; the two registries share no common ID. Trials with a site in Ireland are listed first.

StudyPhaseStatusCountries
A Randomized, Phase 2/3, Open-Label Study to Investigate the Efficacy and Safety of RP2 in Combination with Nivolumab versus Ipilimumab in Combination with Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients with Metastatic Uveal Melanoma
2023-508784-68-00 · CTIS ↗ · Neoplasms
Phase 3 Authorised Germany, Italy, France + 2 more
03

Drugs in Replimune trials

10 compounds

Drugs and biologicals named as interventions in these trials, with the number of this sponsor's trials that name each one. Placebos and generic comparators are excluded.

04

Conditions in Replimune trials

18 conditions
Cancer2Advanced Solid Tumor2Hepatocellular Carcinoma2Advanced Melanoma1Non-Small Cell Lung Cancer (NSCLC)1Microsatellite Instability-High (MSI-H)1Non-melanoma Skin Cancer (NMSC)1Cutaneous Melanoma1Metastatic Uveal Melanoma1Biliary Tract Cancer1Cutaneous Squamous Cell Carcinoma1Advanced Cutaneous Squamous Cell Carcinoma1Metastatic Cutaneous Squamous Cell Carcinoma1Melanoma1Metastatic Melanoma1Merkel Cell Carcinoma1Basal Cell Carcinoma1Locally Advanced Cutaneous Squamous Cell Carcinoma1
05

By trial register

RegisterTrialsRecruiting
Clinical trials in USA84
Clinical trials in UK52
EU register (CTIS)1—

A trial with sites in more than one country appears in each of those registers.

06

Other sponsors in Cancer

SponsorTrials
GRAIL4
Peking University Cancer Hospital & Institute4
Our Lady's Hospice and Care Services3
Conjupro Biotherapeutics3
University of Dublin, Trinity College2
Tempus AI2
Elephas2
First Hospital of China Medical University2
Qinghai Red Cross Hospital2
Wuxi People's Hospital2

Sponsors with the most current trials registered for this condition.

07

Questions about Replimune trials

How many clinical trials does Replimune sponsor?

Replimune is the lead sponsor of 9 current trials on ClinicalTrials.gov in our USA and UK registers, and 1 authorised or ongoing trial in the EU register (CTIS), as of the registry sync on 26 September 2026. Completed and withdrawn studies are not counted.

Are Replimune trials recruiting?

Yes. 4 of its 9 ClinicalTrials.gov trials are recruiting. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Which drugs is Replimune testing?

Its current trials name 10 drugs and biologicals as interventions. The most frequent are Nivolumab (6), RP2 (4), Ipilimumab (2), Atezolizumab (1) and Bevacizumab (1). The number in brackets is how many of its trials name each drug.

Where does this information come from?

Every trial, status, phase and condition on this page is copied from public ClinicalTrials.gov and EU CTIS records by a daily sync, grouped by the sponsor name each registry records. It says nothing about the organisation beyond its registered trials, and it is not medical advice.

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How this page is built

Everything on this page is copied from public registry records — it is not written from memory, and nothing here describes the organisation beyond its registered trials. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our trial registers and groups every current trial by its lead sponsor name, ignoring legal-form suffixes such as Inc. or Ltd. A small, hand-checked list joins the same organisation's different registry names (for example its EU legal entity). There is no AI drafting and no per-sponsor editorial pass. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The the registries data on this page was last retrieved on 26 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.