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Apellis Pharmaceuticals clinical trials

Source: ClinicalTrials.gov, U.S. National Library of Medicine and the EU Clinical Trials Information System (CTIS) — current trials in our USA, UK and EU (CTIS) registers with Apellis Pharmaceuticals as lead sponsor. Synced 26 Sep 2026
6Current trials
3Recruiting now
1Drug in these trials
3Trial registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from ClinicalTrials.gov and CTIS registry records · Last verified · Editorial standards
At a glance

Apellis Pharmaceuticals is the lead sponsor of 6 current clinical trials in our USA, UK and EU (CTIS) registers. 3 are recruiting patients now. The most common phase is Phase 2. The drugs named most often in its trials are Pegcetacoplan. The most-studied condition is C3G.

ClinicalTrials.gov trials by status

  • Recruiting360%
  • Active, closed240%

Trials by phase

  • Phase 2240%
  • Phase 3120%
  • Phase 2/3120%
  • Observational120%
01

Clinical trials sponsored by Apellis Pharmaceuticals

5 on ClinicalTrials.gov
StudyPhaseStatusStartRegisters
A Phase 2, Randomized, Placebo Controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL 3007 in Combination With Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed With Geographic Atrophy Secondary to Age Related Macular Degeneratio
NCT07215390 · ClinicalTrials.gov ↗ · Geographic Atrophy Secondary to Age-related Macular Degeneration
Phase 2 Recruiting 2025-06 USA
A Study of Pegcetacoplan in Pediatric Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)
NCT04901936 · ClinicalTrials.gov ↗ · Paroxysmal Nocturnal Hemoglobinuria (PNH), Paroxysmal Hemoglobinuria
Phase 2 Recruiting 2021-02 UK, USA
A Sequential Phase 2/3 Study of APL2 in Patients With Focal Segmental Glomerulosclerosis
NCT07213960 · ClinicalTrials.gov ↗ · FSGS
Phase 2/3 Recruiting 2026-12 USA
An Open-Label, Nonrandomized, Multicenter Extension Study to Evaluate the Long-term Safety and Efficacy of Pegcetacoplan in Participants With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis
NCT05809531 · ClinicalTrials.gov ↗ · C3G, IC-MPGN, C3 Glomerulopathy
Phase 3 Active, closed 2023-05 UK, USA
A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration
NCT06161584 · ClinicalTrials.gov ↗ · Geographic Atrophy
Observational Active, closed 2023-09 USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Titles and statuses are copied from the registry as published.

02

Apellis Pharmaceuticals in the EU trials register (CTIS)

1 trial

Authorised or ongoing trials in the EU Clinical Trials Information System with Apellis Pharmaceuticals as sponsor. Some are the same study as a ClinicalTrials.gov record above; the two registries share no common ID. Trials with a site in Ireland are listed first.

StudyPhaseStatusCountries
A Sequential Phase 2/3, Single-Arm, Open-Label Study in Adults Followed by a Randomized, Placebo-Controlled, Double-Blind, Multicenter Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults and Adolescents with Focal Segmental Glomerulosclerosis
2025-524448-36-00 · Female Urogenital Diseases and Pregnancy Complications
Phase 3 Authorised France, Portugal, Spain + 4 more
03

Drugs in Apellis Pharmaceuticals trials

1 compound

Drugs and biologicals named as interventions in these trials, with the number of this sponsor's trials that name each one. Placebos and generic comparators are excluded.

04

Conditions in Apellis Pharmaceuticals trials

9 conditions
C3G1IC-MPGN1C3 Glomerulopathy1C3 Glomerulonephritis1Paroxysmal Nocturnal Hemoglobinuria (PNH)1Paroxysmal Hemoglobinuria1Geographic Atrophy Secondary to Age-related Macular Degeneration1FSGS1Geographic Atrophy1
05

By trial register

RegisterTrialsRecruiting
Clinical trials in USA53
Clinical trials in UK21
EU register (CTIS)1—

A trial with sites in more than one country appears in each of those registers.

06

Questions about Apellis Pharmaceuticals trials

How many clinical trials does Apellis Pharmaceuticals sponsor?

Apellis Pharmaceuticals is the lead sponsor of 5 current trials on ClinicalTrials.gov in our USA and UK registers, and 1 authorised or ongoing trial in the EU register (CTIS), as of the registry sync on 26 September 2026. Completed and withdrawn studies are not counted.

Are Apellis Pharmaceuticals trials recruiting?

Yes. 3 of its 5 ClinicalTrials.gov trials are recruiting. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Which drugs is Apellis Pharmaceuticals testing?

Its current trials name 1 drug or biological as interventions. The most frequent are Pegcetacoplan (3). The number in brackets is how many of its trials name each drug.

Where does this information come from?

Every trial, status, phase and condition on this page is copied from public ClinicalTrials.gov and EU CTIS records by a daily sync, grouped by the sponsor name each registry records. It says nothing about the organisation beyond its registered trials, and it is not medical advice.

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How this page is built

Everything on this page is copied from public registry records — it is not written from memory, and nothing here describes the organisation beyond its registered trials. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our trial registers and groups every current trial by its lead sponsor name, ignoring legal-form suffixes such as Inc. or Ltd. A small, hand-checked list joins the same organisation's different registry names (for example its EU legal entity). There is no AI drafting and no per-sponsor editorial pass. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The the registries data on this page was last retrieved on 26 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.