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Compound · clinical trials

Sodium Zirconium Cyclosilicate (SZC)

Also listed in trial records as BNT327, DL1, DL2, DL3
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 8 trials in our USA, UK, China and India registers that name Sodium Zirconium Cyclosilicate (SZC) as an intervention. Synced 24 Sep 2026
8Trials tracked
5Recruiting now
4Lead sponsors
4Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards

Sodium Zirconium Cyclosilicate (SZC) is named as a drug or biological intervention in 8 clinical trials in our USA, UK, China and India trial registers, 5 of which are recruiting. Lead sponsors include BioNTech SE (4), DualityBio Inc. (2) and AstraZeneca (1). Registered phases: Phase 1/2, Phase 2, Phase 3 and Phase 1. Conditions studied include Locally Advanced Breast Cancer; Unresectable Breast Carcinoma; Metastatic Breast Cancer.

01

Clinical trials of Sodium Zirconium Cyclosilicate (SZC)

8 trials
NCT IDStudyPhaseStatusLead sponsorRegister
NCT03813407 An Open-label Study to Assess Safety and Efficacy of SZC in Paediatric Patients With Hyperkalaemia (ClinicalTrials.gov ↗)
Hyperkalaemia
Phase 3 Recruiting AstraZeneca UK, USA, India, China
NCT06953089 DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors (ClinicalTrials.gov ↗)
Solid Tumors
Phase 2 Recruiting DualityBio Inc. USA, China
NCT06827236 A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323 When Used in Combination With Another Investigational Treatment, BNT327, and to Test if That Combination Treatment is Safe and Beneficial for Patients With Advanced Breast Cancer
Locally Advanced Breast Cancer, Unresectable Breast Carcinoma, Metastatic Breast Cancer
Phase 1/2 Recruiting BioNTech SE UK, USA, China
NCT06892548 A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer (ClinicalTrials.gov ↗)
Advanced Lung Cancer
Phase 1/2 Recruiting BioNTech SE UK, USA, China
NCT07042100 A Study to Test the Safety and Tolerability of SBO-154 in Patients With Advanced Solid Tumors. (ClinicalTrials.gov ↗)
Advanced Solid Tumors
Phase 1 Recruiting Sun Pharma Advanced Research Company Limited USA, India
NCT06449209 Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Small-cell Lung Cancer in Combination With Chemotherapy (ClinicalTrials.gov ↗)
Extensive-stage Small-cell Lung Cancer, Small-cell Lung Cancer
Phase 2 Active, closed BioNTech SE UK, USA
NCT06449222 Safety and Preliminary Effectiveness of BNT327, an Investigational Therapy for Breast Cancer, When Given in Combination With Chemotherapy (ClinicalTrials.gov ↗)
Locally Advanced Breast Cancer, Triple Negative Breast Cancer, Metastatic Triple Negative Breast Cancers
Phase 2 Active, closed BioNTech SE UK, USA
NCT05438329 First-in-human Study of DB-1305/BNT325 for Advanced/Metastatic Solid Tumors (ClinicalTrials.gov ↗)
Advanced Solid Tumor
Phase 1/2 Active, closed DualityBio Inc. USA, China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied

12 conditions
Condition (as registered)Trials
Locally Advanced Breast Cancer2
Unresectable Breast Carcinoma1
Metastatic Breast Cancer1
Triple Negative Breast Cancer1
Metastatic Triple Negative Breast Cancers1
Advanced Lung Cancer1
Extensive-stage Small-cell Lung Cancer1
Small-cell Lung Cancer1
Solid Tumors1
Advanced Solid Tumor1
Hyperkalaemia1
Advanced Solid Tumors1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
BioNTech SE4
DualityBio Inc.2
AstraZeneca1
Sun Pharma Advanced Research Company Limited1
04

Trials by country register

RegisterSodium Zirconium Cyclosilicate (SZC) trials
Clinical trials in USA8
Clinical trials in UK5
Clinical trials in China5
Clinical trials in India2

A trial with sites in more than one country appears in each of those registers.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Sodium Zirconium Cyclosilicate (SZC) works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Sodium Zirconium Cyclosilicate (SZC) (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 24 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.