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Compound · clinical trials

Sacituzumab Govitecan-hziy

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 15 trials in our USA, UK, China and Ireland registers that name Sacituzumab Govitecan-hziy as an intervention. Synced 24 Sep 2026
15Trials tracked
4Recruiting now
3Lead sponsors
4Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards

Sacituzumab Govitecan-hziy is named as a drug or biological intervention in 15 clinical trials in our USA, UK, China and Ireland trial registers, 4 of which are recruiting. Lead sponsors include Gilead Sciences (13), Avenzo Therapeutics, Inc. (1) and Tianjin Medical University Second Hospital (1). Registered phases: Phase 3, Phase 2 and Phase 1/2. Conditions studied include Triple Negative Breast Cancer; Non-small Cell Lung Cancer; Endometrial Cancer.

01

Clinical trials of Sacituzumab Govitecan-hziy

15 trials
NCT IDStudyPhaseStatusLead sponsorRegister
NCT05633654 Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
Triple Negative Breast Cancer
Phase 3 Recruiting Gilead Sciences Ireland, UK, USA
NCT06739395 Precision Medicine Trial Based on Molecular Matching Therapy for Patients With Standard Treatment Exhaustion (ClinicalTrials.gov ↗)
Solid Tumor, Precision Medicine
Phase 2 Recruiting Tianjin Medical University Second Hospital China
NCT05867251 Study of AVZO-021 in Patients With Advanced Solid Tumors (ClinicalTrials.gov ↗)
Advanced Solid Tumor, HR+/HER2- Breast Cancer, HR+, HER2-, Advanced Breast Cancer
Phase 1/2 Recruiting Avenzo Therapeutics, Inc. USA
NCT06926920 A Study of Sacituzumab Govitecan Given at an Alternative Dose and Schedule in Participants With Advanced Triple-Negative Breast Cancer (ClinicalTrials.gov ↗)
Triple Negative Breast Cancer
Phase 1/2 Recruiting Gilead Sciences USA
NCT04639986 Asian Study of Sacituzumab Govitecan (IMMU-132) in HR+/HER2- Metastatic Breast Cancer (MBC) (ClinicalTrials.gov ↗)
Metastatic Breast Cancer
Phase 3 Active, closed Gilead Sciences China
NCT05089734 Study of Sacituzumab Govitecan (SG) Versus Docetaxel in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) (ClinicalTrials.gov ↗)
Non-Small Cell Lung Cancer
Phase 3 Active, closed Gilead Sciences UK, USA
NCT05382286 Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer (ClinicalTrials.gov ↗)
Triple Negative Breast Cancer, PD-L1 Positive
Phase 3 Active, closed Gilead Sciences UK, USA
NCT05382299 Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients With Previously Untreated Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer (ClinicalTrials.gov ↗)
Triple Negative Breast Cancer, PD-L1 Negative
Phase 3 Active, closed Gilead Sciences UK, USA, China
NCT05840211 Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy (ClinicalTrials.gov ↗)
Locally Advanced or Unresectable Metastatic Breast Cancer, Stage IV Breast Cancer
Phase 3 Active, closed Gilead Sciences UK, USA, China
NCT06486441 Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants With Endometrial Cancer After Platinum-Based Chemotherapy and Immunotherapy (ASCENT-GYN-01/GOG-3104/ENGOT-en26) (ClinicalTrials.gov ↗)
Endometrial Cancer
Phase 3 Active, closed Gilead Sciences UK, USA, China
NCT03547973 Study of Sacituzumab Govitecan in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread (ClinicalTrials.gov ↗)
Metastatic Urothelial Cancer
Phase 2 Active, closed Gilead Sciences UK, USA
NCT03964727 Study of Sacituzumab Govitecan in Participants With Metastatic Solid Tumors
Metastatic Solid Tumor
Phase 2 Active, closed Gilead Sciences USA
NCT04454437 Study of Sacituzumab Govitecan in Chinese Patients With Metastatic Triple-negative Breast Cancer Who Received at Least Two Prior Treatments (ClinicalTrials.gov ↗)
Metastatic Triple-negative Breast Cancer
Phase 2 Active, closed Gilead Sciences China
NCT05186974 Study of Sacituzumab Govitecan Combinations in First-line Treatment of Participants With Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC)
Non-small Cell Lung Cancer
Phase 2 Active, closed Gilead Sciences UK, USA
NCT05633667 Study of Novel Treatment Combinations in Patients With Lung Cancer (ClinicalTrials.gov ↗)
Lung Cancer, Advanced or Metastatic Non-Small-Cell Lung Cancer, Resectable Non-Small-Cell Lung Cancer
Phase 2 Active, closed Gilead Sciences UK, USA

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied

21 conditions
Condition (as registered)Trials
Triple Negative Breast Cancer4
Non-small Cell Lung Cancer1
Endometrial Cancer1
Lung Cancer1
Advanced or Metastatic Non-Small-Cell Lung Cancer1
Resectable Non-Small-Cell Lung Cancer1
PD-L1 Positive1
Metastatic Urothelial Cancer1
Locally Advanced or Unresectable Metastatic Breast Cancer1
Stage IV Breast Cancer1
PD-L1 Negative1
Non-Small Cell Lung Cancer1
Metastatic Solid Tumor1
Advanced Solid Tumor1
HR+/HER2- Breast Cancer1
HR+, HER2-, Advanced Breast Cancer1
CCNE1 Amplification1
Solid Tumor1
Precision Medicine1
Metastatic Breast Cancer1
Metastatic Triple-negative Breast Cancer1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Gilead Sciences13
Avenzo Therapeutics, Inc.1
Tianjin Medical University Second Hospital1
04

Trials by country register

A trial with sites in more than one country appears in each of those registers.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Sacituzumab Govitecan-hziy works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Sacituzumab Govitecan-hziy (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 24 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.