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Compound · clinical trials

PLB1004

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 7 trials in our China and USA registers that name PLB1004 as an intervention. Synced 25 Sep 2026
7Trials tracked
3Recruiting now
3Lead sponsors
2Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards

PLB1004 is named as a drug or biological intervention in 7 clinical trials in our China and USA trial registers, 3 of which are recruiting. Lead sponsors include Avistone Biotechnology Co., Ltd. (5), Beijing Pearl Biotechnology Limited Liability Company (1) and Avistone Pharmaceutical๏ผˆNingbo๏ผ‰Co., LTD. (1). Registered phases: Phase 2, Phase 1/2, Phase 1 and Phase 3. Conditions studied include Non-Small-Cell Lung Cancer; Non-Small Cell Lung Cancer; NSCLC (Non-small Cell Lung Cancer).

01

Clinical trials of PLB1004

7 trials
NCT IDStudyPhaseStatusLead sponsorRegister
NCT06574347 Vebreltinib Plus PLB1004 as the First-line Therapy for Patients With EGFRm+/MET+ Locally Advanced or Metastatic NSCLC. (ClinicalTrials.gov ↗)
Non-Small-Cell Lung Cancer
Phase 2 Recruiting Avistone Biotechnology Co., Ltd. China
NCT07336732 Andamertinib With or Without Platinum-doublet Chemotherapy Versus Platinum-doublet Chemotherapy in Patients With NSCLC Harboring Atypical EGFR Mutations (ClinicalTrials.gov ↗)
Non-Small-Cell Lung Cancer
Phase 2 Recruiting Avistone Biotechnology Co., Ltd. China
NCT06046495 A Study of the Oral EGFR Inhibitor PLB1004 in Non-Small Cell Lung Cancer
Non-Small Cell Lung Cancer
Phase 1 Recruiting Avistone Biotechnology Co., Ltd. USA
NCT07063329 Phase I/II Study of PLB1004 Combined With Platinum-based Doublet Chemotherapy in Patients With EGFR Mutation-positive (ClinicalTrials.gov ↗)
NSCLC (Non-small Cell Lung Cancer)
Phase 1/2 Not yet open Avistone Pharmaceutical๏ผˆNingbo๏ผ‰Co., LTD. China
NCT07285148 A Study to Evaluate ANS014004 in Combination With EGFR-TKI in Non-Small Cell Lung Cancer
Non-Small Cell Lung Cancer, EGFR Mutation, Metastatic Lung Cancer
Phase 1/2 Not yet open Beijing Pearl Biotechnology Limited Liability Company USA
NCT06281964 Efficacy and Safety Evaluation of PLB1004 in Patients With Non-squamous NSCLC Harboring EGFR Exon 20 Insertion. (ClinicalTrials.gov ↗)
Non-Small-Cell Lung Cancer
Phase 3 By invitation Avistone Biotechnology Co., Ltd. China
NCT06015503 A Phase โ…ก Study Assessing the Safety and Efficacy of PLB1004 in EGFR ex20ins Mutation Patients With Advanced and Metastatic Non-small Cell Lung Cancer(NSCLC) (ClinicalTrials.gov ↗)
NSCLC (Non-small Cell Lung Cancer)
Phase 2 Active, closed Avistone Biotechnology Co., Ltd. China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied

6 conditions
Condition (as registered)Trials
Non-Small-Cell Lung Cancer3
Non-Small Cell Lung Cancer2
NSCLC (Non-small Cell Lung Cancer)2
EGFR Mutation1
Metastatic Lung Cancer1
MET Alteration1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Avistone Biotechnology Co., Ltd.5
Beijing Pearl Biotechnology Limited Liability Company1
Avistone Pharmaceutical๏ผˆNingbo๏ผ‰Co., LTD.1
04

Trials by country register

A trial with sites in more than one country appears in each of those registers.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how PLB1004 works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists PLB1004 (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 25 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.