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Compound · clinical trials

Mevrometostat clinical trials

Also listed in trial records as PF-06821497, Mervometostat, EZH2i
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 5 trials in our China, USA and UK registers that name Mevrometostat as an intervention. Synced 25 Sep 2026
5Current trials
3Recruiting now
2Lead sponsors
3Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards
At a glance

Mevrometostat is named as an intervention in 5 current clinical trials in our China, USA and UK registers. 3 are recruiting patients now. The most common phase is Phase 3. The sponsor with the most trials is Pfizer (4). The most-studied condition is Metastatic Castration-Resistant Prostate Cancer.

Trials by status

  • Recruiting360%
  • Not yet open120%
  • Active, closed120%

Trials by phase

  • Phase 3360%
  • Phase 1120%
  • Phase 1/2120%
01

Clinical trials of Mevrometostat

5 trials
StudyPhaseStatusLead sponsorRegisters
A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.
NCT06629779 · ClinicalTrials.gov ↗ · Metastatic Castration-Resistant Prostate Cancer
Phase 3 Recruiting Pfizer UK, USA, China
This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naรฏve.
NCT07028853 · ClinicalTrials.gov ↗ · Metastatic Castration Sensitive Prostate Cancer (mCSPC), Hormone Sensitive Prostate Cancer, Prostate Cancer
Phase 3 Recruiting Pfizer UK, USA, China
A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma
NCT03460977 · ClinicalTrials.gov ↗ · Metastatic Castration Resistant Prostate Cancer (mCRPC), Small Cell Lung Cancer (SCLC), Follicular Lymphoma (FL)
Phase 1 Recruiting Pfizer USA, China
Single-Arm Clinical Study of EZH2i in Combination With Glofitamab + GemOx in Patients With Relapsed/ Refractory DLBCL
NCT07643805 · ClinicalTrials.gov ↗ · DLBCL
Phase 1/2 Not yet open The First Affiliated Hospital with Nanjing Medical University China
A Study to Learn About the Investigational Medicine Called PF-06821497 (Mevrometostat) in Men With mCRPC Who Were Previously Treated With Abiraterone Acetate for Prostate Cancer (MEVPRO-1).
NCT06551324 · ClinicalTrials.gov ↗ · Metastatic Castrate Resistant Prostate Cancer (mCRPC)
Phase 3 Active, closed Pfizer UK, USA, China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Mevrometostat

10 conditions
Metastatic Castration-Resistant Prostate Cancer1Metastatic Castrate Resistant Prostate Cancer (mCRPC)1Metastatic Castration Resistant Prostate Cancer (mCRPC)1Small Cell Lung Cancer (SCLC)1Follicular Lymphoma (FL)1Metastatic Castration Sensitive Prostate Cancer (mCSPC)1Hormone Sensitive Prostate Cancer1Prostate Cancer1Cancer of the Prostate1DLBCL1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Pfizer4
The First Affiliated Hospital with Nanjing Medical University1
04

By country register

RegisterTrialsRecruiting
Clinical trials in China53
Clinical trials in USA43
Clinical trials in UK32

A trial with sites in more than one country appears in each of those registers.

05

Related compounds

06

Questions about Mevrometostat trials

How many clinical trials are testing Mevrometostat?

5 current trials in our China, USA and UK registers name Mevrometostat (also registered as PF-06821497) as a drug or biological intervention, as of the registry sync on 25 September 2026. Completed and withdrawn studies are not counted.

Are Mevrometostat trials recruiting patients?

Yes. 3 of the 5 trials are recruiting: 3 with sites in China, 3 with sites in USA and 2 with sites in UK. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Mevrometostat clinical trials?

Pfizer (4) and The First Affiliated Hospital with Nanjing Medical University (1). The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Mevrometostat works or whether it is effective, and it is not medical advice.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how Mevrometostat works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Mevrometostat (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 25 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.