MCLA-129 is named as an intervention in 3 current clinical trials in our China and USA registers. 1 is recruiting patients now. The most common phase is Phase 1/2. The sponsor with the most trials is Betta Pharmaceuticals Co., Ltd (2). The most-studied condition is Non-Small Cell Lung Cancer Metastatic.
| Study | Phase | Status | Lead sponsor | Registers |
|---|---|---|---|---|
|
Study of MCLA-129 in Combination With Ensartinib in Patients With Advanced Solid Tumors.
NCT07448116 · ClinicalTrials.gov ↗ · Solid Advanced Tumor
|
Phase 1/2 | Recruiting | Betta Pharmaceuticals Co., Ltd. | China |
|
Study of MCLA-129 in the Treatment of Advanced Non-small Cell Lung Cancer with AGA and MET Amplification.
NCT06885840 · ClinicalTrials.gov ↗ · Non-Small Cell Lung Cancer
|
Phase 2 | Not yet open | Betta Pharmaceuticals Co., Ltd. | China |
|
Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination
NCT04868877 · Non-Small Cell Lung Cancer Metastatic, Gastric Cancer, Esophageal Squamous Cell Carcinoma
|
Phase 1/2 | Active, closed | Merus B.V. | USA |
Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.
| Lead sponsor | Trials |
|---|---|
| Betta Pharmaceuticals Co., Ltd. | 2 |
| Merus B.V. | 1 |
| Register | Trials | Recruiting |
|---|---|---|
| Clinical trials in China | 2 | 1 |
| Clinical trials in USA | 1 | 0 |
A trial with sites in more than one country appears in each of those registers.
3 current trials in our China and USA registers name MCLA-129 as a drug or biological intervention, as of the registry sync on 25 September 2026. Completed and withdrawn studies are not counted.
Yes. 1 of the 3 trials is recruiting: 1 with sites in China. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.
Betta Pharmaceuticals Co., Ltd (2) and Merus B.V (1). The number in brackets is how many trials each organisation leads.
Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how MCLA-129 works or whether it is effective, and it is not medical advice.
Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how MCLA-129 works or whether it is effective. Each trial links to its own record so you can check it yourself.
This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists MCLA-129 (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 25 Sep 2026.