| NCT06686576 |
A Study of Neoadjuvant QL1706 in Participants With Untreated dMMR/MSI-H Resectable Colon Cancer (ClinicalTrials.gov ↗) Colon Cancer |
Phase 3 |
Recruiting |
Qilu Pharmaceutical Co., Ltd. |
China |
| NCT06786026 |
QL1706 Plus Chemotherapy +/- Bevacizumab in 1L Treatment of R/mTNBC (ClinicalTrials.gov ↗) TNBC, Triple Negative Breast Cancer |
Phase 2 |
Recruiting |
Fudan University |
China |
| NCT06787183 |
SCRT(Short Course Radiotherapy) Combined With CAPOX Plus QL1706 for Rectal Cancer Liver Metastases (ClinicalTrials.gov ↗) Locally Advanced Rectal Cancer With Liver Metastases |
Phase 2 |
Recruiting |
Fujian Cancer Hospital |
China |
| NCT06897046 |
Perioperative Study of Iparomlimab and Tuvonralimab in Resectable NSCLC (ClinicalTrials.gov ↗) Non-small Cell Lung Cancer (NSCLC), II-IIIB |
Phase 2 |
Recruiting |
Cancer Institute and Hospital, Chinese Academy of Medical Sciences |
China |
| NCT06908382 |
Neoadjuvant QL1706 Therapy for ESCC (ClinicalTrials.gov ↗) Locally Advanced Resectable Esophageal Squamous Cell Carcinoma |
Phase 2 |
Recruiting |
Shandong Provincial Hospital |
China |
| NCT06917092 |
QL1706-Based Therapy Post-PD-1/L1 Failure in Advanced Endometrial Cancer (ClinicalTrials.gov ↗) Endometrial Adenocarcinoma, Endometrial Cancer |
Phase 2 |
Recruiting |
Tianjin Medical University Cancer Institute and Hospital |
China |
| NCT06949111 |
Radiotherapy + Systemic Therapy as Conversion Therapy for pMMR/MSS T4M0 Colon Cancer๏ผNeo-Color๏ผ Colon Cancer |
Phase 2 |
Recruiting |
Hebei Medical University Fourth Hospital |
China |
| NCT06951997 |
QL1706 Plus Chidamide, AG as First-line Treatment for Metastatic Pancreatic Cancer (ClinicalTrials.gov ↗) Metastatic Pancreatic Cancer |
Phase 2 |
Recruiting |
Tianjin Medical University Cancer Institute and Hospital |
China |
| NCT07014150 |
Neoadjuvant Therapy of Iparomlimab and Tuvonralimab Combined With Lenvatinib for Hepatocellular Carcinoma (ClinicalTrials.gov ↗) Hepatocellular Carcinoma Resectable |
Phase 2 |
Recruiting |
Peking Union Medical College Hospital |
China |
| NCT07082179 |
A Prospective Phase II Clinical Study of Immunotherapy Combined With Chemotherapy for Stage III Unresectable Non-small Cell Lung Cancer (ClinicalTrials.gov ↗) NSCLC |
Phase 2 |
Recruiting |
Jiangsu Cancer Institute & Hospital |
China |
| NCT07090317 |
Iparomlimab and Tuvonralimab in HNSCC (ClinicalTrials.gov ↗) Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma |
Phase 2 |
Recruiting |
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University |
China |
| NCT07091305 |
A Study of QL1706 Combined With Chemotherapy Induction on Sequential Immunotherapy Consolidation in Patients With Limited-Stage Small Cell Lung Cancer After Chemoradiotherapy (ClinicalTrials.gov ↗) Limited-stage Small Cell Lung Cancer (LS-SCLC), Chemoradiotherapy, Induction Therapy |
Phase 2 |
Recruiting |
Shanghai Chest Hospital |
China |
| NCT07101744 |
Iparomlimab and Tuvonralimab Combined With Nimotuzumab in Recurrent or Metastatic NPC After First-line Treatment Failure: A Single-arm Phase IIa Clinical Trial (ClinicalTrials.gov ↗) Nasopharyngeal Carcinoma (NPC), First-line Treatment Failure Nasopharyngeal Carcinoma |
Phase 2 |
Recruiting |
Sun Yat-sen University |
China |
| NCT07127822 |
Assessing Iparomlimab and Tuvonralimab in Recurrent or Metastatic MSI-H/dMMR Gastric Cancer (ClinicalTrials.gov ↗) Gastric / Gastroesophageal Junction Adenocarcinoma, MSI-H Cancer |
Phase 2 |
Recruiting |
Peking University |
China |
| NCT07150247 |
Safety and Efficacy of IB-FOLFIRI in BRAF V600E-Mutant Metastatic Colorectal Cancer (ClinicalTrials.gov ↗) BRAF V600 Colorectal Cancer |
Phase 2 |
Recruiting |
Sun Yat-sen University |
China |
| NCT07165847 |
Neoadjuvant Radiotherapy Plus Tegafur, Oxaliplatin and Iparomlimab and Tuvonralimab in Resectable Gastric and GE-junction Cancer : A Randomized, Two-arm, Prospective Trial (TRIUNITE-05) (ClinicalTrials.gov ↗) Immunotherapy, Gastric Cancer (GC), Radiotherapy |
Phase 2 |
Recruiting |
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University |
China |
| NCT07179900 |
Radiotherapy Combined With QL1706 and Bevacizumab for Unresectable Non-metastatic Hepatocellular Carcinoma (ClinicalTrials.gov ↗) Hepatocellular Carcinoma |
Phase 2 |
Recruiting |
Hebei Medical University Fourth Hospital |
China |
| NCT07180160 |
Iparomlimab and Tuvonralimab (QL1706) in Patients With HR-positive, HER2-negative Advanced Breast Cancer (ClinicalTrials.gov ↗) Advanced Breast Cancer |
Phase 2 |
Recruiting |
Wenjin Yin |
China |
| NCT07232654 |
Iparomlimab/Tuvonralimab Injection Plus CCRT in LACC (ClinicalTrials.gov ↗) LOCALLY ADVANCED CERVICAL CANCERS |
Phase 2 |
Recruiting |
Cancer Institute and Hospital, Chinese Academy of Medical Sciences |
China |
| NCT07256236 |
SKB264 Plus QL1706 in Recurrent or Metastatic Cervical Cancer (ClinicalTrials.gov ↗) Cervical Cancer |
Phase 2 |
Recruiting |
Fujian Cancer Hospital |
China |
| NCT07286240 |
QL1706 Combined With Chemotherapy and Anlotinib for the Treatment of Recurrent Ovarian Cancer (ClinicalTrials.gov ↗) Treatment of Recurrent Ovarian Cancer |
Phase 2 |
Recruiting |
Affiliated Cancer Hospital & Institute of Guangzhou Medical University |
China |
| NCT07289997 |
Iparomlimab and Tuvonralimab Combined With Apatinib and Irinotecan Hydrochloride for the Treatment of Advanced Alpha-fetoprotein-producing Gastric Cancer (AFPGC) (ClinicalTrials.gov ↗) AFP Gastric or Gastroesophageal Junction Adenocarcinoma, PD-1/CTLA-4, AFPGC |
Phase 2 |
Recruiting |
Hebei Medical University Fourth Hospital |
China |
| NCT07290010 |
The Efficacy and Safety of Iparomlimab and Tuvonralimab Injection Combined With Chemotherapy as the First-line Treatment for Esophageal Squamous Cell Carcinoma (ClinicalTrials.gov ↗) Esophageal Squamous Cell Carcinoma (ESCC) |
Phase 2 |
Recruiting |
Hebei Medical University Fourth Hospital |
China |
| NCT07327788 |
QL1706 in Combination With Bevacizumab and RALOX HAIC for Hepatocellular Carcinoma With Vp3/4 PVTT (ClinicalTrials.gov ↗) Hepatecellular Carcinoma, RALOX-HAIC๏ผHepatic Arterial Infusion Chemotherapy With Raltitrexed and Oxaliplatin, Bevacizumab |
Phase 2 |
Recruiting |
Nanfang Hospital, Southern Medical University |
China |
| NCT07328009 |
A Platform Trial for Personalized and Adaptive Therapies in Hepatocellular Carcinoma (ClinicalTrials.gov ↗) Hepato Cellular Carcinoma (HCC) |
Phase 2 |
Recruiting |
Fudan University |
China |
| NCT07330596 |
QL1706 Combined With Chemotherapy in the Treatment of Immune-mediated NSCLC (ClinicalTrials.gov ↗) NSCLC (Advanced Non-small Cell Lung Cancer) |
Phase 2 |
Recruiting |
Anhui Provincial Cancer Hospital |
China |
| NCT07384416 |
QL1706 Plus Lenvatinib in Previously Treated Penile Cancer (ClinicalTrials.gov ↗) Penile Cancer |
Phase 2 |
Recruiting |
Sun Yat-sen University |
China |
| NCT07392346 |
Safety and Efficacy of Fruquintinib Plus Nab-Paclitaxel and Iparomlimab and Tuvonralimab Injection in the Second-Line Treatment for Immunotherapy-experienced Advanced Gastric Cancer (ClinicalTrials.gov ↗) Gastric Cancer Adenocarcinoma Metastatic |
Phase 2 |
Recruiting |
Dai, Guanghai |
China |
| NCT07396324 |
Neoadjuvant QL1706 in Patients With Hormone Receptor Positive, HER2-negative Breast Cancer (ClinicalTrials.gov ↗) HR-positive/HER2-negative Breast Cancer |
Phase 2 |
Recruiting |
RenJi Hospital |
China |
| NCT07646301 |
Iparomlimab and Tuvonralimab Plus Paclitaxel and Platinum as Neoadjuvant Therapy for Locally Advanced Cervical Cancer (ClinicalTrials.gov ↗) Uterine Cervical Neoplasms, Locally Advanced |
Phase 2 |
Recruiting |
Sun Yat-sen University |
China |
| NCT07776080 |
Iparomlimab and Tuvonralimab With Lenvatinib, Radiotherapy, and HAIC for Hepatocellular Carcinoma With Portal Vein Tumor Thrombus (ClinicalTrials.gov ↗) HCC - Hepatocellular Carcinoma |
Phase 2 |
Recruiting |
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology |
China |
| NCT07256782 |
A Study of QLC5508 Combinations in Patients With Advanced Solid Tumors (ClinicalTrials.gov ↗) Advanced Solid Tumor |
Phase 1/2 |
Recruiting |
Qilu Pharmaceutical Co., Ltd. |
China |
| NCT07291947 |
PULSAR Combined With Immunotherapy and Chemotherapy (ClinicalTrials.gov ↗) Cholangiocarcinoma |
Phase 1/2 |
Recruiting |
Wang Xin |
China |
| NCT07178171 |
A Study of QL1706 Combined With Short-Cycle Anthracyclines or Taxanes for the Treatment of Early-Stage TNBC (ClinicalTrials.gov ↗) TNBC, Triple Negative Breast Cancer |
Phase 1 |
Recruiting |
Xijing Hospital |
China |
| NCT07546383 |
A Study Investigating the Efficacy and Safety of the Combination of Iparomlimab and Tuvonralimab With or Without Chemotherapy in Second-line and Subsequent Treatments for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (ClinicalTrials.gov ↗) Squamous Cell Carcinoma of Head and Neck |
Not applicable |
Recruiting |
The Second Affiliated Hospital of Hainan Medical University |
China |
| NCT07004335 |
Efficacy and Safety of Iparomlimab and Tuvonralimab Injection in Combination With Bevacizumab After Progression on Anti-PD-(L)1 Therapy in Advanced Melanoma: A Prospective, Single-Arm, Exploratory Clinical Study (ClinicalTrials.gov ↗) PD-(L)1, CTLA-4, Advanced Melanoma |
Phase 4 |
Not yet open |
Hebei Medical University Fourth Hospital |
China |
| NCT07729605 |
FOLFIRI Plus Bevacizuamb and QL1706 in Second-Line Treatment for mCRC (ClinicalTrials.gov ↗) Colorectal Cancer Metastatic, Microsatellite Stable (MSS) Colorectal Cancer (CRC) |
Phase 3 |
Not yet open |
Sun Yat-sen University |
China |
| NCT05976568 |
A Study of QL1706 in Combination With Bevacizumab and/or Chemotherapy as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma (ClinicalTrials.gov ↗) Hepatocellular Carcinoma |
Phase 2/3 |
Not yet open |
Qilu Pharmaceutical Co., Ltd. |
China |
| NCT06446388 |
Study of QLS31905 and/or QL1706 Combination With Chemotherapy in the Advanced Malignant Solid Tumors (ClinicalTrials.gov ↗) Advanced Solid Tumor |
Phase 2 |
Not yet open |
Qilu Pharmaceutical Co., Ltd. |
China |
| NCT06750861 |
QL1706 Plus Chemotherapy With AG Regime as First-line Treatment of Advanced PDAC (ClinicalTrials.gov ↗) Pancreatic Adenocarcinoma |
Phase 2 |
Not yet open |
Cancer Institute and Hospital, Chinese Academy of Medical Sciences |
China |
| NCT06751277 |
QL1706 Combined with Chemotherapy in the Treatment of Recurrent or Metastatic Endometrial Cancer (ClinicalTrials.gov ↗) Recurrent or Metastatic Endometrial Cancer |
Phase 2 |
Not yet open |
xiang yang |
China |
| NCT07007728 |
Iparomlimab/Tuvonralimab Combined With Bevacizumab and CAPEOX as Conversion Therapy for Colorectal Cancer Liver Metastasis (ClinicalTrials.gov ↗) Colorectal Neoplasms, Secondary Malignant Neoplasm of Liver |
Phase 2 |
Not yet open |
Peking University Cancer Hospital & Institute |
China |
| NCT07041788 |
Iparomlimab and Tuvonralimab Combined With SFRT and Definitive Chemoradiotherapy in Locoregionally Advanced Bulky HNSCC (ClinicalTrials.gov ↗) Cancer |
Phase 2 |
Not yet open |
Second Affiliated Hospital of Nanchang University |
China |
| NCT07070713 |
Efficacy and Safety of FOLFOX+Cetuximab vs. FOLFOXIRI+Bevacizumab Both With QL1706 in First-Line Treatment of Left-Sided mCRC (ClinicalTrials.gov ↗) Metastatic Colorectal Cancer With Left-sided Primary Tumor, Immunotherapy |
Phase 2 |
Not yet open |
Fujian Cancer Hospital |
China |
| NCT07131501 |
A Single-Arm, Multicenter, Exploratory Clinical Study of TACE Combined With Iparomlimab and Tuvonralimab Injection (QL1706) and Lenvatinib for Perioperative Treatment of Resectable Hepatocellular Carcinoma (ClinicalTrials.gov ↗) Hepatocellular Carcinoma, Immunotherapy, Preoperative |
Phase 2 |
Not yet open |
The First Affiliated Hospital with Nanjing Medical University |
China |
| NCT07156682 |
QL1706 Plus XELOX as Neoadjuvant Therapy for MSS/pMMR Clinical Stage III Colon Cancer (ClinicalTrials.gov ↗) Colon Cancer, MSS/pMMR, QL1706 |
Phase 2 |
Not yet open |
Qilu Hospital of Shandong University |
China |
| NCT07246317 |
Evaluation of Neoadjuvant Therapy With Trastuzumab, Pertuzumab, Docetaxel, and QL1706 in Early or Locally Advanced HER2+ Breast Cancer (ClinicalTrials.gov ↗) Breast Cancer |
Phase 2 |
Not yet open |
Tianjin Medical University Cancer Institute and Hospital |
China |
| NCT07286942 |
Stereotactic Body Radiotherapy With Sequential Iparomlimab and Tuvonralimab (QL1706) + Chemotherapy as Neoadjuvant Therapy in Patients With Resectable Non-small-cell Lung Cancer in China (LUNG-Nanjing01): a Single-arm, Single-centre, Phase 2 Trial (ClinicalTrials.gov ↗) NSCLC, NSCLC (Non-small Cell Lung Cancer) |
Phase 2 |
Not yet open |
Jiangsu Cancer Institute & Hospital |
China |
| NCT07315035 |
QL1706-SOX vs SOX Alone as Neoadjuvant Therapy for Resectable Diffuse-Type Gastric Cancer (ClinicalTrials.gov ↗) Gastric Cancer Stage III |
Phase 2 |
Not yet open |
The First Affiliated Hospital with Nanjing Medical University |
China |
| NCT07353268 |
Phase Ib/II Study of QL1706 + Fruquintinib + SCRT vs. Standard Third-Line Therapy in Unresectable Liver-Metastatic pMMR/MSS Colorectal Cancer: Safety, Tolerability, and Efficacy. (ClinicalTrials.gov ↗) Colorectal Cancer |
Phase 2 |
Not yet open |
Tao Zhang |
China |
| NCT07372079 |
Neoadjuvant Therapy for Early Triple-Negative Breast Cancer: A Response-Guided Approach Using Iparomlimab and Tuvonralimab Injection in Combination With Chemotherapy (ClinicalTrials.gov ↗) Breast Cancer, Neoadjuvant Therapy, Immune Checkpoint Inhibitors |
Phase 2 |
Not yet open |
Tianjin Medical University Cancer Institute and Hospital |
China |
| NCT07413601 |
Phase 2 Clinical Study of Iparomlimab and Tuvonralimab (QL1706) in Combination With Platinum Chemotherapy Versus Platinum Chemotherapy in the Treatment of Second-/Third-line Triple Negative Breast Cancer (TNBC) (ClinicalTrials.gov ↗) Triple Negative Breast Cancer Metastatic |
Phase 2 |
Not yet open |
Cancer Institute and Hospital, Chinese Academy of Medical Sciences |
China |
| NCT07446387 |
A Clinical Study of Iparomlimab and Tuvonralimab Combined With Bevacizumab and Alternating Triweekly CAPOX/mCAPIRI Regimen as First-line Treatment for Unresectable Advanced Colorectal Cancer (ClinicalTrials.gov ↗) Metastatic Colorectal Cancer (CRC) |
Phase 2 |
Not yet open |
Jiangsu Cancer Institute & Hospital |
China |
| NCT07649473 |
QL1706 Combined With Standard Therapy for Conversion Therapy of Synchronous Liver Metastases From Colon Cancer: a Multicenter, Single-arm, Exploratory Study (ClinicalTrials.gov ↗) Colon Cancer, Synchronous Liver Metastases |
Phase 2 |
Not yet open |
Fujian Medical University |
China |
| NCT07663513 |
Iparomlimab and Tovorilimab (QL1706) Combined With Bevacizumab and Chemotherapy as Neoadjuvant Therapy for Advanced Ovarian Cancer (ClinicalTrials.gov ↗) Ovarian Cancers |
Phase 2 |
Not yet open |
Fudan University |
China |
| NCT07741617 |
A Prospective, Single-Arm, Multicenter Clinical Study of High-Risk Localized and Locally Advanced Renal Clear Cell Carcinoma (ClinicalTrials.gov ↗) Urologic Neoplasms |
Phase 2 |
Not yet open |
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School |
China |
| NCT07828873 |
A Single-Arm Study of QL1706 Combined With DOS as Neoadjuvant Therapy for Locally Advanced Gastric/GEJ Adenocarcinoma (ClinicalTrials.gov ↗) Locally Advanced Gastric or Gastroesophageal Junction Adenocarcinoma |
Phase 2 |
Not yet open |
The First Affiliated Hospital of Zhengzhou University |
China |
| NCT07829874 |
Cryoablation Combined With QL1706 (Iparomlimab/Tuvonralimab) Plus Lenvatinib in Patients With Advanced Biliary Tract Cancer. (ClinicalTrials.gov ↗) Biliary Tract Cancer (BTC) |
Phase 2 |
Not yet open |
Fudan University |
China |
| NCT06602063 |
Surgery for Relapsed Ovarian Cancer in Precision (ClinicalTrials.gov ↗) Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma |
Phase 1/2 |
Not yet open |
Shanghai Gynecologic Oncology Group |
China |
| NCT06822985 |
QL1706 As Second-line Treatment in Patients with Advanced Hepatocellular Carcinoma (ClinicalTrials.gov ↗) HCC - Hepatocellular Carcinoma |
Phase 1 |
Not yet open |
Wan-Guang Zhang |
China |
| NCT07139587 |
The Efficacy and Safety of Iparomlimab/Tuvonralimab (Anti PD-1/CTLA-4) Combined With Albumin-bound Paclitaxel in Second-line Treatment of Patients With Advanced Gastric/Gastroesophageal Junction Adenocarcinoma (ClinicalTrials.gov ↗) Gastric Cancer, Gastroesophageal Junction Adenocarcinoma |
Not applicable |
Not yet open |
Qingxia Li |
China |
| NCT07538193 |
Iparomlimab and Tuvonralimab Plus Chemotherapy Before Surgery for Stage III Lung Cancer (ClinicalTrials.gov ↗) Carcinoma, Non-Small-Cell Lung (NSCLC), Neoplasm Staging, Lymphatic Metastasis |
Not applicable |
Not yet open |
Tang-Du Hospital |
China |
| NCT06313970 |
First-line Regimen With QL1706 Plus Chemo ยฑ Bev in PDAC Patients (ClinicalTrials.gov ↗) Pancreatic Cancer |
Phase 2 |
Active, closed |
Fudan University |
China |
| NCT06892925 |
QL1706 Combined With Lenvatinib and GEMOX as First - Line Treatment for Unresectable Biliary Tract Tumors Biliary Tract Tumors |
Phase 2 |
Active, closed |
Eastern Hepatobiliary Surgery Hospital |
China |
| NCT07205497 |
QL1706 Plus Neoadjuvant Chemotherapy Followed by Type I Hysterectomy for Locally Advanced Cervical Cancer (ClinicalTrials.gov ↗) Neoadjuvant Immunotherapy, Locally Advanced Cervical Cancer |
Phase 2 |
Active, closed |
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University |
China |
| NCT07776639 |
Iparomlimab and Tuvonralimab Injection (QL1706) Combined With DOS as Neoadjuvant Therapy for Locally Advanced Adenocarcinoma of the Stomach and Gastroesophageal Junction (ClinicalTrials.gov ↗) Gastroesophageal Junction Adenocarcinoma, Gastric Adenocarcinoma |
Phase 2 |
Active, closed |
Yongxu Jia |
China |
| NCT06809530 |
Intrathecal Dual Checkpoint Inhibitor (PD-1 and CTLA-4) in Combination With Pemetrexed for Leptomeningeal Metastasis (ClinicalTrials.gov ↗) Leptomeningeal Metastasis, Pemetrexed, PD-1 Inhibitor |
Phase 1/2 |
Active, closed |
Guangzhou Medical University |
China |