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Compound · clinical trials

HLX43 1

Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 7 trials in our China and USA registers that name HLX43 1 as an intervention. Synced 24 Sep 2026
7Trials tracked
5Recruiting now
1Lead sponsor
2Country registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 โ€” Top 14 finalist
Compiled from ClinicalTrials.gov registry records ยท Last verified ยท Editorial standards

HLX43 1 is named as a drug or biological intervention in 7 clinical trials in our China and USA trial registers, 5 of which are recruiting. The lead sponsor is Shanghai Henlius Biotech. Registered phases: Phase 2 and Phase 1/2. Conditions studied include Non Small Cell Lung Cancer; Gastric or Gastroesophageal Junction Adenocarcinoma; Colorectal Cancer (CRC).

01

Clinical trials of HLX43 1

7 trials
NCT IDStudyPhaseStatusLead sponsorRegister
NCT06839066 A Phase II Study to Evaluate HLX43 in Subjects With Recurrent/Metastatic Nasopharyngeal Carcinoma Failed or Intolerance to Second-line Therapy (ClinicalTrials.gov ↗)
Nasopharyngeal Carcinoma (NPC)
Phase 2 Recruiting Shanghai Henlius Biotech China
NCT06907615 A Phase II Clinical Study to Evaluate HLX43 in Subjects With Advanced Non-small Cell Lung Cancer (NSCLC) (ClinicalTrials.gov ↗)
Non Small Cell Lung Cancer
Phase 2 Recruiting Shanghai Henlius Biotech USA, China
NCT07106892 Phase II, Open-label, Multicenter Study to Evaluate the Efficacy and Safety of HLX43 (an Anti-PD-L1 ADC) in Subjects With Advanced Colorectal Cancer (ClinicalTrials.gov ↗)
Colorectal Cancer (CRC)
Phase 2 Recruiting Shanghai Henlius Biotech China
NCT07115485 Phase II, Open-label, Multicenter Study to Evaluate the Efficacy and Safety of HLX43 (an Anti-PD-L1 ADC) in Subjects With Advanced Gastric or Gastroesophageal Junction Adenocarcinoma (ClinicalTrials.gov ↗)
Gastric or Gastroesophageal Junction Adenocarcinoma
Phase 2 Recruiting Shanghai Henlius Biotech China
NCT07253142 A Phase II Clinical Study to Evaluate HLX43 in Combination With Serplulimab in Subjects With Advanced Lung Cancer (ClinicalTrials.gov ↗)
Non Small Cell Lung Cancer, Small Cell Lung Cancer
Phase 2 Recruiting Shanghai Henlius Biotech China
NCT07487519 Phase II Study of HLX43 Monotherapy or Combined With Immune Checkpoint Inhibitors in Patients With Locally Advanced, Recurrent, or Metastatic Triple-negative Breast Cancer. (ClinicalTrials.gov ↗)
Breast Cancer (Triple Negative Breast Cancer (TNBC))
Phase 2 Not yet open Shanghai Henlius Biotech China
NCT07358585 A Phase Ib/II Study to Evaluate HLX43 Combined With HLX07 or Serplulimab in Patients With Advanced or Metastatic Colorectal Cancer (ClinicalTrials.gov ↗)
Colon Cancer Adenocarcinoma
Phase 1/2 Not yet open Shanghai Henlius Biotech China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied

7 conditions
Condition (as registered)Trials
Non Small Cell Lung Cancer2
Gastric or Gastroesophageal Junction Adenocarcinoma1
Colorectal Cancer (CRC)1
Colon Cancer Adenocarcinoma1
Nasopharyngeal Carcinoma (NPC)1
Small Cell Lung Cancer1
Breast Cancer (Triple Negative Breast Cancer (TNBC))1
03

Sponsors

lead sponsor per trial
Lead sponsorTrials
Shanghai Henlius Biotech7
04

Trials by country register

A trial with sites in more than one country appears in each of those registers.

How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records โ€” it is not written from memory, and nothing here describes how HLX43 1 works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists HLX43 1 (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 24 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician โ€” our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us โ€” we correct promptly and log it.