RO7890597: Participants will receive RO7890597 as per the schedule described in the protocol.
Placebo: Participants will receive matching placebo as per the schedule described in the protocol.
Rabeprazole: Participants will receive rabeprazole as per the schedule described in the protocol.
Itraconazole: Participants will receive itraconazole as per the schedule described in the protocol.
Study summary
This study will evaluate the safety, pharmacokinetics (PK), and activity of single and multiple doses of RO7890597 compared with placebo in healthy volunteers. The study includes single ascending dose (SAD) stage, multiple ascending dose (MAD) stage, food-effect and proton pump inhibitor (PPI) stages, and a supplemental drug-drug interaction (DDI) stage.
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Agreement to adhere to the contraception requirements.
* Body mass index of 18 to 30 kilograms per square meter (kg/m²).
Exclusion Criteria:
* Pregnant, breastfeeding, or intending to become pregnant during the study or required contraception period.
* Treatment with investigational biologic therapy within 90 days or 5 elimination half-lives, whichever is longer, before study drug initiation.
* Treatment with investigational non-biologic therapy within 28 days or 5 elimination half-lives, whichever is longer, before study drug initiation.
* Treatment with immunosuppressive medication within 28 days or 5 elimination half-lives, whichever is longer, before study drug initiation.
* Treatment with any vaccine within 14 days prior to initiation of study drug, or within 28 days for a live or live attenuated vaccine.
* Poor peripheral venous access.
* Major surgery within 28 days before study drug initiation or planned major surgery during the study.
* Current infection or recent infection requiring antibiotics as defined in the protocol.
* History of malignancy within 5 years before screening, except for specified adequately treated cancers.
* History of clinically significant drug or food allergy.
Primary outcome measure(s)
Incidence and Severity of Adverse Events (AEs) — Up to approximately 12 weeks
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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