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Clinical Trials in the USA / NCT07794592
Starting soon Phase 1

A Study Comparing Two Ways of Taking Olomorasib (LY3537982) in Healthy Participants

NCT07794592 · tracked via the Priya Life Science USA tracker
Sponsor
Eli Lilly and Company
Phase
Phase 1
Started
2026-08
Last updated
2026-08-31

Condition(s) studied

Healthy Volunteers

Investigational drug(s) / intervention(s)

Olomorasib testOlomorasib reference

Olomorasib test: Administered orally

Olomorasib reference: Administered orally

Study summary

The main purpose of this study is to compare how much and how quickly olomorasib gets into the bloodstream when it is taken in 2 different ways, and to check for any side effects. For each participant, the study will last about 6 weeks and will include 1 stay in the Clinical Research Unit (CRU) which consists of 7 nights.

Eligibility

Sex
ALL
Min age
18 Years
Max age
55 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, and cardiac monitoring. * Have a body mass index (BMI) within the range 18.0 to 30.0 kilograms per square meter (kg/m2) * Participants assigned male at birth (AMAB) or assigned female at birth (AFAB) who are individuals not of childbearing potential (INOCBP) * Able to comply with the 7-night stay at the study site. Exclusion Criteria: * History or presence of any of the following conditions, such as metabolic disease, biliary disease, gastrointestinal disease, hematological disease, neurological disease, presence of hepatic disease, active cardiovascular disease or history of myocardial infarction or unstable angina within 6 months prior to the first dose of olomorasib * Have an abnormal blood pressure or pulse rate * Have known allergies to olomorasib or related compounds. * Have clinically significant history of multiple or severe drug hypersensitivity reactions or drug allergies as determined by the investigator, such as anaphylaxis, hepatotoxicity, or treatment with steroids or epinephrine. * History or presence of any illness or psychiatric condition that would interfere with the ability to provide informed consent or comply with study instructions, * Show evidence of Human immunodeficiency virus (HIV) infection or positive HIV antibodies at screening. * Have a positive hepatitis C antibody test unless a confirmatory HCV RNA test is negative. * Have evidence of hepatitis B at screening that is, positive test for hepatitis B surface antigen, Hepatitis B Virus Deoxyribonucleic Acid (HBV DNA) or both.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Fortrea Clinical Research Unit Daytona Beach Florida

More Eli Lilly and Company trials in the USA

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07794592 on ClinicalTrials.gov ↗ ← All trials in the USA