Partial enteral nutrition (PEN) with dairy eliminationDairy elimination alone
Partial enteral nutrition (PEN) with dairy elimination: Patients in the PEN with dairy elimination group will receive 50% calories from Kate Farms Standard 1.2 formula and 50% dairy free regular diet.
Dairy elimination alone: Participants in this group will be on a dairy-free regular diet alone.
Study summary
This study aims to introduce a new dietary therapy for Eosinophilic Esophagitis (EoE) patients by using partial enteral nutrition (PEN) to enhance remission rates and explore how this approach affects immune function, gut microbiota, and environmental toxin exposures.
Eligibility
Sex
ALL
Min age
1 Year
Max age
21 Years
Healthy volunteers
No
Inclusion Criteria:
* Pediatric patients 1 year to 21 of age presenting with chronic symptoms of dysphagia, odynophagia, vomiting or heartburn, chronic abdominal pain, weight loss, picky eating, to outpatient gastroenterology clinic and are planning to undergo EGD for evaluation.
Exclusion Criteria:
* Non-English-Speaking Subjects, adults unable to consent, wards of the state, pregnant women, and prisoners will be excluded from the study.
* Patients with autoimmune conditions such as inflammatory bowel disease. Patients with prior esophageal or intestinal surgeries.
* Patients with history of eating disorders or ARFID.
* Patients with fistulizing or fibrotic disease on baseline EGD.
* Patients who have received proton pump inhibitory therapy in the past month.
Primary outcome measure(s)
Feasibility of PEN assessed by 3-day diet record — 3 months Feasibility and adherence of PEN in EoE patients will be evaluated using 3-day diet records collected at 2 weeks post initiation of the study and at 3 months.
Tolerability of PEN in EoE patients will be assessed by stool quality evaluated using the Bristol Stool Chart. — 3 months Bristol stool chart will be used to assess stool quality at 2 weeks and at month 3.
Clinical and endoscopic remission rates assessed by mucosal eosinophilia and Eosinophilic Esophagitis Histology Scoring System (EoE-HSS) from GI tissue biopsies — 3 months For baseline and three-month tissue collection, GI tissue biopsies will be obtained at the time of clinical endoscopy assess mucosal eosinophilia and EoE-HSS.
Immune profiles assessed by blood markers — 3 months Immune profiles in EoE patients will be assessed by blood markers using CBC with differential, comprehensive metabolic panel, C-Reactive Protein, and Erythrocyte Sedimentation Rate before and after PEN and dairy elimination.
Microbiota shifts in EoE patients — 3 months Microbiota shifts will be assessed from stool metabolomics, urine metabolomics, oral swab microbiome, and esophageal brushing of EoE before and after PEN and dairy free diets.
Environmental contaminants assessed by blood serum levels — 3 months Environmental contaminants assessed by CBC with differential before and after PEN with dairy elimination.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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