Gocatamig: Intravenous (IV) administration
I-DXd: IV administration
Atezolizumab: IV administration
Carboplatin: IV administration
Etoposide: IV administration
Rescue Medications: Participants will receive rescue medications at the investigator's discretion. Recommended rescue medications include tocilizumab for treatment of cytokine release syndrome (CRS); dexamethasone, acetaminophen, and diphenhydramine for CRS/infusion-related reaction (IRR) prophylaxis; and 5-hydroxytryptamine 3 (5-HT3) receptor antagonist, neurokinin 1 (NK-1) receptor antagonist, and corticosteroid for prevention of nausea and vomiting.
Researchers are looking for new ways to treat extensive-stage small cell lung cancer (ES-SCLC). ES-SCLC is a type of lung cancer that has spread throughout the lung, to the other lung, or to other parts of the body.
A standard (usual) treatment for ES-SCLC uses both chemotherapy and immunotherapy.
* Chemotherapy is a treatment that works to destroy cancer cells or stop them from growing.
* Immunotherapy is a treatment that helps the immune system fight cancer.
Gocatamig and I-DXd (short for ifinatamab deruxtecan) are study medicines. Researchers want to know if giving gocatamig and I-DXd together can treat ES-SCLC. Researchers will also look at giving the study medicines with standard treatment. Gocatamig is a T-cell engager therapy. I-DXd is an antibody drug conjugate.
* T-cell engager therapy is a certain type of immunotherapy that uses T-cells to find and destroy cancer cells.
* A T-cell is a type of white blood cell, which are cells that help the body fight infection.
* An antibody drug conjugate (ADC) is a treatment that attaches to a protein on cancer cells and delivers treatment to destroy those cells.
The goals of this study are to learn:
* About the safety of combining gocatamig and I-DXd and if people tolerate them together
* If people who receive gocatamig and I-DXd have ES-SCLC respond, which means the cancer gets smaller or goes away
| Facility | City | Region | Status |
|---|---|---|---|
| Providence Medical Foundation ( Site 0124) | Santa Rosa | California | Recruiting |
| University of Colorado, Anschutz Cancer Pavilion ( Site 0125) | Aurora | Colorado | Recruiting |
| Orlando Health Cancer Institute ( Site 0108) | Orlando | Florida | Recruiting |
| Saint Elizabeth Medical Center Edgewood ( Site 0112) | Edgewood | Kentucky | Recruiting |
| Washington University School of Medicine ( Site 0134) | St Louis | Missouri | Recruiting |
| John Theurer Cancer Center at Hackensack University Medical Center ( Site 0101) | Hackensack | New Jersey | Recruiting |
| Providence Cancer Institute, Franz Clinic - Eastside ( Site 0107) | Portland | Oregon | Recruiting |
| Avera Cancer Institute- Research ( Site 0104) | Sioux Falls | South Dakota | Recruiting |
| The University of Tennessee Medical Center ( Site 0120) | Knoxville | Tennessee | Recruiting |
| Lt. Col. Luke Weathers, Jr. VA Medical Center ( Site 0133) | Memphis | Tennessee | Recruiting |
| SCRI Oncology Partners ( Site 7000) | Nashville | Tennessee | Recruiting |
| Houston Methodist Hospital - Houston Methodist Neal Cancer Center ( Site 0113) | Houston | Texas | Recruiting |
| University of Virginia Health System ( Site 0122) | Charlottesville | Virginia | Recruiting |
| CEMIC ( Site 1903) | Caba. | Buenos Aires | Recruiting |
| Hospital Austral ( Site 1901) | Pilar | Buenos Aires | Recruiting |
| Sanatorio Parque ( Site 1900) | Rosario | Santa Fe Province | Recruiting |
| FALP ( Site 0200) | Santiago | Region M. de Santiago | Recruiting |
| Pontificia Universidad Catolica de Chile ( Site 0202) | Santiago | Region M. de Santiago | Recruiting |
| Bradfordhill ( Site 0201) | Santiago | Region M. de Santiago | Recruiting |
| Beijing Cancer Hospital ( Site 1604) | Beijing | Beijing Municipality | Recruiting |
| Fujian Provincial Cancer Hospital ( Site 1607) | Fuzhou | Fujian | Recruiting |
| Southern Medical University Nanfang Hospital ( Site 1608) | Guangzhou | Guangdong | Recruiting |
| Jiangmen Central Hospital ( Site 1611) | Jiangmen | Guangdong | Recruiting |
| The First Affiliated Hospital of Nanchang University ( Site 1610) | Nanchang | Jiangxi | Recruiting |
| Shanghai East Hospital ( Site 1600) | Shanghai | Shanghai Municipality | Recruiting |
| Sichuan Cancer hospital. ( Site 1609) | Chengdu | Sichuan | Recruiting |
| The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 1602) | Hangzhou | Zhejiang | Recruiting |
| Taizhou Hospital of Zhejiang Province ( Site 1601) | Taizhou | Zhejiang | Recruiting |
| Universitaetsklinikum Tuebingen-Department of Internal Medicine VIII - Medical Oncology, ECTU, Pne ( Site 0401) | Tübingen | Baden-Wurttemberg | Recruiting |
| Universitaetsklinikum Jena ( Site 0403) | Jena | Thuringia | Recruiting |
| Errikos Dunant Hospital Center ( Site 0501) | Athens | Attica | Recruiting |
| THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA" ( Site 0502) | Athens | Attica | Recruiting |
| Athens Medical Center ( Site 0504) | Athens | Attica | Recruiting |
| European Interbalkan Medical Center ( Site 0500) | Thessaloniki | Greece | Recruiting |
| European Interbalkan Medical Center ( Site 0505) | Thessaloniki | Greece | Recruiting |
| Rambam Health Care Campus ( Site 0602) | Haifa | Israel | Recruiting |
| Sheba Medical Center ( Site 0601) | Ramat Gan | Israel | Recruiting |
| IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 0702) | Meldola | Forli-Cesena | Recruiting |
| Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 0701) | Milan | Italy | Recruiting |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 0700) | Roma | Italy | Recruiting |
+ 12 more sites — see the full list on the official registry below.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07227597 on ClinicalTrials.gov ↗ ← All trials in the USA