A Clinical Study to Evaluate the Efficacy of Activated Silk™ 27P-α in Subjects, Aged 35-65 Years of Age, to Improve the Signs of Aging, by Comparing to a Placebo

Inclusion Criteria: * Healthy individuals, between the ages of 35 - 65 years of age, with no known medical conditions that interfere with study participation, are the priority. * Subject has signed a written Informed Consent prior to Day -7. * 100% of subjects have crow's feet and at least one of the following: forehead lines/wrinkles (e.g. vertical lines between eyebrows, horizontal lines above the eyebrow), marionette lines, nasolabial folds. * 50% of subjects have self-perceived sensitive skin. * 20% of the subjects are not 100% Caucasian. Exclusion Criteria: * Subject is pregnant, nursing, or planning to become pregnant. * Subject is currently using medication likely to affect the response to investigational formulation. * Subject had a fever in the last 12 hours prior to the start of the study. * Subject has a pacemaker or significant medical history of hepatic, renal, cardiac, pulmonary, digestive, hematological, neurological, locomotor or psychiatric disease; cancer; multiple sclerosis; high blood pressure; thrombosis; phlebitis; insulin-dependent diabetes; or any such related medical condition(s) that may interfere with the completion of the study. * The Subject used a form of retinol on their face in the past six months. * The Subject used any prescription skincare products on their face in the last six months. * The Subject has received any laser, chemical peel, or other facial resurfacing treatment such as microdermabrasion, dermablading or microneedling in the past four weeks. * The Subject received Botox, Dysport, other muscle relaxers or injectable skin fillers in the face during the past six months. * Subject has a known allergy or sensitivity to any ingredient in the aqueous skincare formulation provided for their use in the trial . * Subject is currently participating in another study utilizing facial products. * Subject is blind, visually impaired or decisionally impaired.