A Trial Evaluating Efficacy of AGA2118 in PostMenopausal Women wIth Low Bone MasS (ARTEMIS)

Inclusion Criteria: * Healthy, ambulatory, postmenopausal women age ≥ 55 to ≤ 80. * BMD T-score of ≤ -2.5 to \> -3.5 at the lumbar spine, total hip, or femoral neck. Exclusion Criteria: * History of vertebral fracture, or fragility fracture of the wrist, humerus, proximal femur, or pelvis. * Vitamin D deficiency. * Known intolerance to calcium or vitamin D supplements. * Untreated hyper- or hypothyroidism. * Current hyper- or hypoparathyroidism. * Elevated transaminases. * Significantly impaired renal function. * Current hypo- or hypercalcemia. * Positive for HIV, hepatitis C virus, or hepatitis B surface antigen. * Malignancy within the last 5 years. * Diagnosis of a familial cancer syndrome or known genetic mutation that increases risk of cancer. * Myocardial infarction or stroke within the past 12 months. * Use of agents affecting bone metabolism.