Extension Study of Two Doses of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)
Condition(s) studied
Investigational drug(s) / intervention(s)
linsitinib: Study medication taken twice daily by mouth
Study summary
The overall study objective is to continue to assess the efficacy, safety, pharmacokinetics, and pharmacodynamics of linsitinib in subjects who were enrolled in the prior VGN-TED-301 through Week 24. These subjects include VGN-TED-301 Week 24 proptosis non-responders or subjects who relapse during the Follow-Up Period of VGN-TED-301.
Eligibility
Primary outcome measure(s)
- Percentage of Subjects who are Proptosis Responders at Week 24 — 24 weeks
Percentage of subjects with a ≥ 2 mm reduction of proptosis from baseline as determined by exophthalmometer
Trial sites (2)
| Facility | City | Region | Status |
|---|---|---|---|
| Bascom Palmer Eye Institute | Miami | Florida | Recruiting |
| West Virginia University Eye Institute | Morgantown | West Virginia | Recruiting |
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Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06112340 on ClinicalTrials.gov ↗ ← All trials in the USA