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Clinical Trials in the USA / NCT06003426
Active, not recruiting Phase 3

A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Idiopathic Pulmonary Fibrosis

NCT06003426 · tracked via the Priya Life Science USA tracker
Sponsor
Bristol-Myers Squibb
Phase
Phase 3
Started
2023-09-14
Last updated
2026-03-24

Condition(s) studied

Idiopathic Pulmonary Fibrosis

Investigational drug(s) / intervention(s)

BMS-986278BMS-986278 Placebo

BMS-986278: Specified dose on specified days

BMS-986278 Placebo: Specified dose on specified days

Study summary

The purpose of this study is to evaluate the efficacy, safety, and tolerability of BMS-986278 in participants with Idiopathic Pulmonary Fibrosis.

Eligibility

Sex
ALL
Min age
40 Years
Max age
Healthy volunteers
No
Inclusion Criteria * Subjects with IPF aged ≥ 40 years at the time of signing the informed consent. * Diagnosis of IPF within 7 years prior to screening that is supported by centrally read chest high-resolution computed tomography (HRCT) obtained at screening and verification of usual interstitial pneumonia. * If on pirfenidone or nintedanib, participants must have been on a stable dose for at least 90 days prior to screening. * If not currently on pirfenidone or nintedanib, participants must not have received either of these medications within 28 days prior to screening. * Women who are of childbearing potential must have a highly effective form of contraception and must provide a negative urine/serum pregnancy test. * Men who are sexually active with women of childbearing potential agree to use male barrier contraception. Exclusion Criteria * History of stroke or transient ischemic attack within 3 months prior to screening. * Participants who exhibit symptoms of heart failure at rest. * Participants who have a current malignancy or a previous malignancy with less than 2 years free of recurrence or a biopsy that is suspicious for malignancy and the possibility of malignancy cannot be reasonably excluded following additional clinical, laboratory, or other diagnostic evaluations. * Other protocol-defined Inclusion/Exclusion criteria apply

Primary outcome measure(s)

Trial sites (390)

FacilityCityRegionStatus
Local Institution - 0189 Birmingham Alabama
Local Institution - 0361 Phoenix Arizona
Local Institution - 0396 La Jolla California
Local Institution - 0193 Los Angeles California
Local Institution - 0398 Los Angeles California
Local Institution - 0389 Orange California
Local Institution - 0405 Sacramento California
Local Institution - 0185 San Francisco California
Local Institution - 0186 Stanford California
Local Institution - 0363 Aurora Colorado
Local Institution - 0194 Denver Colorado
Local Institution - 0175 New Haven Connecticut
Local Institution - 0151 Newark Delaware
Local Institution - 0367 Washington D.C. District of Columbia
Local Institution - 0101 Brandon Florida
Local Institution - 0436 Clearwater Florida
Local Institution - 0425 DeBary Florida
Local Institution - 0079 Gainesville Florida
Local Institution - 0352 Hialeah Florida
Local Institution - 0370 Kissimmee Florida
Local Institution - 0502 Leesburg Florida
Local Institution - 0153 Loxahatchee Groves Florida
Local Institution - 0187 Ocala Florida
Local Institution - 0418 Pensacola Florida
Local Institution - 0206 St. Petersburg Florida
Local Institution - 0364 Tampa Florida
Local Institution - 0372 Dublin Georgia
Local Institution - 0178 Chicago Illinois
Local Institution - 0183 Chicago Illinois
Local Institution - 0058 Chicago Illinois
Local Institution - 0085 Maywood Illinois
Local Institution - 0325 Peoria Illinois
Local Institution - 0180 Iowa City Iowa
Local Institution - 0204 Kansas City Kansas
Local Institution - 0393 Louisville Kentucky
Local Institution - 0354 Baltimore Maryland
Local Institution - 0380 Boston Massachusetts
Local Institution - 0040 Boston Massachusetts
Local Institution - 0472 Ann Arbor Michigan
Local Institution - 0096 Chesterfield Missouri

+ 350 more sites — see the full list on the official registry below.

More Bristol-Myers Squibb trials in the USA

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06003426 on ClinicalTrials.gov ↗ ← All trials in the USA