Aerobic Exercise (AER): Aerobic exercise will be performed by utilizing aerobic exercise equipment 3 times per week.
Rehabilitation: Rehabilitative program is focused on completion of activities of daily living, initiation, appropriate behavior and community integration for five days per week at the Centre for Neuro Skills.
Study summary
The purpose of this study is to examine the effects of individualized aerobic exercise regimen on recovery after traumatic brain injury (TBI).Investigators will determine if exercise facilitates recovery by facilitating neuroplasticity and decreasing neuroinflammation.
Eligibility
Sex
ALL
Min age
18 Years
Max age
60 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* All participants will provide informed consent and have to comply with the procedures of the study.
* Age will range from 18 to 60 years.
* Except for the non-injured control group, subjects will be required to have experienced TBI.
* All participants should be fluent in English or Spanish.
* All participants should have the ability to comply with the research protocol.
* Capable of exercising in aerobic exercise equipment (with or without trunk support).
* Able to walk independently with or without a device
Exclusion Criteria:
* Current diagnosis of degenerative neurological disease.
* A history of cerebral vascular accidents.
* A history of major psychosis as defined by DSM-IV.
* Subjects receiving physical therapy in a location that is not CNS.
* Pregnancy.
* A history of previous TBI requiring hospitalization.
* Inability to cooperate
* Orthopedic impairment that compromises exercise performance
* Any cardiovascular or respiratory condition that jeopardizes patient health during exercise.
Primary outcome measure(s)
Aerobic Exercise Induced Changes in Cardio Pulmonary Exercise (CPET) at baseline — Baseline CPET will allow us to determine oxygen consumption (VO2). Results will be reported as change in VO2 levels.
Aerobic Exercise Induced Changes in Cardio Pulmonary Exercise (CPET) at Week 4 — Week 4 CPET will allow us to determine oxygen consumption (VO2). Results will be reported as change in VO2 levels.
Aerobic Exercise Induced Changes in Cardio Pulmonary Exercise (CPET) at Week 8 — Week 8 CPET will allow us to determine oxygen consumption (VO2). Results will be reported as change in VO2 levels.
Aerobic Exercise Induced Changes in Cardio Pulmonary (CPET) at Week 12 — Week 12 CPET will allow us to determine oxygen consumption (VO2). Results will be reported as change in VO2 levels.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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