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Clinical Trials in the USA / NCT05544019
Recruiting Phase 1

Study of SGR-1505 in Mature B-Cell Neoplasms

NCT05544019 · tracked via the Priya Life Science USA tracker
Sponsor
Schrödinger, Inc.
Phase
Phase 1
Started
2023-04-10
Last updated
2026-02-13

Condition(s) studied

Mature B-Cell NeoplasmNon Hodgkin LymphomaDLBCLWaldenstrom MacroglobulinemiaMALT LymphomaFollicular LymphomaPediatric-Type Follicular LymphomaIRF4 Gene RearrangementEBV-Positive DLBCL, NosBurkitt LymphomaPlasmablastic LymphomaHigh-grade B-cell LymphomaPrimary Cutaneous Follicle Center LymphomaPrimary Effusion LymphomaMantle Cell LymphomaDLBCL Germinal Center B-Cell TypePrimary Mediastinal Large B Cell LymphomaT-Cell/Histiocyte Rich LymphomaALK-Positive Large B-Cell LymphomaPrimary Cutaneous Diffuse Large B-Cell LymphomaSplenic Marginal Zone LymphomaChronic Lymphocytic LeukemiaNodal Marginal Zone LymphomaHHV8-Positive DLBCL, NosLymphoplasmacytic LymphomaDuodenal-Type Follicular Lymphoma

Investigational drug(s) / intervention(s)

SGR-1505

SGR-1505: SGR-1505 will be administered orally.

Study summary

The purpose of this study is to evaluate safety and tolerability and to determine the maximum tolerated dose (MTD) or maximum administered dose (MAD) and/or recommended dose (RD) of SGR-1505.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: * Subject must have a history of histologically or cytologically confirmed mature B-cell malignancy. * Subject must have measurable or detectable disease according to the applicable disease-specific classification system and meet criteria for initiation of treatment. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. * Life expectancy ≥ 12 weeks. Exclusion Criteria: * The subject is in need of immediate cytoreductive therapy (unless the patient has no remaining treatment choice with potential benefit). * Subject has previous invasive malignancy in the last 2 years. * Subject has a known allergy to SGR-1505 or excipients of SGR-1505. * Subject has symptomatic or active CNS involvement of disease. * Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding that would place the participant at increased risk to the use of an investigational drug.

Primary outcome measure(s)

Trial sites (36)

FacilityCityRegionStatus
Banner Health - MD Anderson Cancer Center Gilbert Arizona Recruiting
Christiana Care Hospital - Helen F Graham Cancer Center Newark Delaware Recruiting
Napa Research Pompano Beach Florida Recruiting
Beth Israel Deaconess Medical Center Boston Massachusetts Recruiting
Regional Cancer Care Associates Hackensack New Jersey Recruiting
Roswell Park Comprehensive Cancer Center Buffalo New York Recruiting
Weill Cornell New York New York Recruiting
Montefiore Medical Center The Bronx New York Recruiting
Duke University Durham North Carolina Recruiting
Gabrail Cancer & Research Center Canton Ohio Recruiting
The Ohio State University - The James Cancer Hospital Columbus Ohio Recruiting
Oregon Health and Science University - Knight Cancer Institute Portland Oregon Recruiting
Rhode Island Hospital Providence Rhode Island Recruiting
University of Texas Southwestern Dallas Texas Recruiting
Fred Hutchinson Cancer Center Seattle Washington Recruiting
Medical College of Wisconsin Milwaukee Wisconsin Recruiting
AP-HP Hôpital Henri-Mondor Créteil France Recruiting
Institut Gustave Roussy Villejuif France Recruiting
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e C. Arrigo - Presidio Ospedaliero SS Antonio e Biagio e Cesare Arrigo, Ospedale Civile Alessandria Italy Recruiting
ASST Grande Ospedale Metropolitano Niguarda Milan Italy Recruiting
IRCCS Ospedale San Raffaele Milan Italy Recruiting
AOU Citta della Salute e della Scienza di Torino - Ospedale le Molinette Torino Italy Recruiting
Azienda Ospedaliera - Universitaria Integrata di Verona - Ospedale Borgo Roma Verona Italy Recruiting
Institute of Oncology, ARENSIA Exploratory Medicine Chisinau Moldova Recruiting
Uniwersyteckie Centrum Kliniczne, Osrodek Badan Klinicznych Wczesnych Faz Gdansk Poland Recruiting
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi Lodz Poland Recruiting
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Warsaw Poland Recruiting
ARENSIA Institutul Oncologic Prof. Dr. Alexandru Trestioreanu Bucuresti Bucharest Romania Recruiting
ARENSIA Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj Napoca Cluj-Napoca Romania Recruiting
Institut Catala d'Oncologia - L'Hospitalet Barcelona Spain Recruiting
Hospital Universitario Quironsalud Madrid Madrid Spain Recruiting
START Madrid - CIOCC Madrid Spain Recruiting
START Madrid - Hospital Fundacion Jimenez Diaz Madrid Spain Recruiting
Clinica Universidad de Navarra - Pamplona Pamplona Spain Recruiting
Hospital Clinico Universitario de Salamanca Salamanca Spain Recruiting
ARENSIA Research Clinic at Harmony Health Clinic Kyiv Ukraine Recruiting

More Schrödinger, Inc. trials in the USA

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05544019 on ClinicalTrials.gov ↗ ← All trials in the USA