Acoustic Cluster Therapy (ACT) With Chemotherapy for the Treatment of Locally Advanced Pancreatic Cancer

NCT06850623 · tracked via the Priya Life Science UK tracker

Sponsor

EXACT Therapeutics AS

Phase

Phase 2

Started

2025-06-19

Last updated

2026-04-03

Condition(s) studied

Locally Advanced Pancreatic Adenocarcinoma

Investigational drug(s) / intervention(s)

Acoustic Cluster TherapyModified FOLFIRINOX

Acoustic Cluster Therapy: Drug: PS101; Device: Ultrasound

Modified FOLFIRINOX: Chemotherapy

Study summary

The purpose of the study is to assess the efficacy and safety of Acoustic Cluster Therapy (ACT) when given in addition to chemotherapy for treatment of Locally Advanced Pancreatic Cancer.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Not deemed suitable for primary curative surgery and have radiographic and pathological disease consistent with inoperable LAPC or borderline resectable pancreatic cancer. * Suitable to receive treatment with mFOLFIRINOX according to the Investigator's assessment. Exclusion Criteria: • Any prior anti-cancer treatment for pancreatic cancer (e.g. chemotherapy, surgery, radiation). Palliative bypass procedure and bile duct stenting are allowed.

Primary outcome measure(s)

ORR (Overall response rate), defined as the number of participants with measurable disease at baseline who have a confirmed Complete Response or confirmed Partial Response according to RECIST Version 1.1. — From baseline to end of treatment (up to Week 24)

Trial sites (10)

Facility	City	Region	Status
HonorHealth Research Institute	Scottsdale	Arizona	Recruiting
Stanford Cancer Center Palo Alto	Stanford	California	Recruiting
Beth Israel Deaconess Medical Center - Division of Hematology/Oncology	Boston	Massachusetts	Recruiting
Henry Ford Centre	Detroit	Michigan	Recruiting
Sidney Kimmel Cancer Center, Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	Recruiting
Allegheny General Hospital	Pittsburgh	Pennsylvania	Recruiting
Brown University Cancer Institute	Providence	Rhode Island	Recruiting
CAMBRIDGE CANCER TRIALS CENTRE-Addenbrooke's Hospital	Cambridge	Cambridge	Recruiting
Gary Weston Centre- Imperial College Healthcare- Du Cane Road	Hammersmith	London	Recruiting
The Royal Marsden- Downs Road	Sutton	Surrey	Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06850623 on ClinicalTrials.gov ↗ ← All trials in the UK