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Clinical Trials in the UK / NCT05999994
Recruiting Phase 2

A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer

NCT05999994 · tracked via the Priya Life Science UK tracker
Sponsor
Eli Lilly and Company
Phase
Phase 2
Started
2020-01-22
Last updated
2026-08-07

Condition(s) studied

NeoplasmsChildAdolescent

Investigational drug(s) / intervention(s)

RamucirumabCyclophosphamideVinorelbineGemcitabineDocetaxelAbemaciclibIrinotecanTemozolomide

Ramucirumab: Administered IV

Cyclophosphamide: Administered orally

Vinorelbine: Administered IV

Gemcitabine: Administered IV

Docetaxel: Administered IV

Abemaciclib: Administered orally

Irinotecan: Administered IV

Temozolomide: Administered orally

Study summary

The main purpose of the master is to help the research sites and sponsor carry out several clinical trials more efficiently by providing a common research protocol. Individual clinical trials under this master protocol define drug/disease-specific research goals and activities to test them. New studies will be added as new drugs emerge against different cancers. Participation in the trial will depend on how long the benefit lasts.

Eligibility

Sex
ALL
Min age
1 Year
Max age
39 Years
Healthy volunteers
No
Inclusion Criteria: Participants must meet all of the inclusion criteria below. Additional criteria are specified in the protocol amendment (individual addenda) to which the participant will enroll. * Have either measurable or evaluable disease using standard techniques by the Response Evaluation Criteria in Solid Tumors, Version 1.1 (RECIST 1.1). * The participant has a Lansky (\<16 years of age) or Karnofsky (≥16 years of age) performance score of at least 50. * Participants must have discontinued all previous treatments for cancer or investigational agents greater than or equal to (≥)7 days after the last dose and must have recovered from clinically significant side effects. * The participant has adequate hematologic and organ function. * Female participants of childbearing potential must have a negative urine or serum pregnancy test within 7 days prior to first dose. * Both female and male participants of childbearing potential must agree to use highly effective contraceptive precautions during the trial and for at least 3 months following the last dose of study drug. Participants will be ineligible if they meet any of the exclusion criteria below. Additional criteria are specified in the protocol amendment to which the participant will enroll. * Participants with severe and/or uncontrolled concurrent medical disease or psychiatric illness/social situation that, in the opinion of the investigator, could cause unacceptable safety risks or compromise compliance with the protocol. * Participants who have active infections requiring therapy. * Participants who have had allogeneic bone marrow or solid organ transplant. * Participants who have had, or are planning to have, certain invasive procedures. * Female participants who are pregnant or breastfeeding.

Primary outcome measure(s)

Trial sites (72)

FacilityCityRegionStatus
Childrens Hospital of Alabama Birmingham Alabama Not Yet Recruiting
Phoenix Children's Hospital Phoenix Arizona Recruiting
Phoenix Children's Hospital Phoenix Arizona Recruiting
Childrens Hospital of Los Angeles Los Angeles California Completed
UCLA Medical Center Los Angeles California Not Yet Recruiting
Children's Hospital of Orange County Orange California Recruiting
Children's Hospital of Colorado Denver Colorado Recruiting
Children's National Medical Center Washington D.C. District of Columbia Recruiting
Golisano Children's Hospital of Southwest Florida Fort Myers Florida Recruiting
Mayo Clinic in Florida Jacksonville Florida Recruiting
Children's Healthcare of Atlanta, Inc. at Egleston Atlanta Georgia Not Yet Recruiting
Ann & Robert H Lurie Children's Hospital of Chicago Chicago Illinois Recruiting
Riley Hospital for Children Indianapolis Indiana Active Not Recruiting
Dana-Farber Cancer Institute Boston Massachusetts Not Yet Recruiting
C.S. Mott Children's Hospital Ann Arbor Michigan Not Yet Recruiting
University of Minnesota Hospital Minneapolis Minnesota Not Yet Recruiting
Children's Mercy Hospital Kansas City Missouri Recruiting
Washington University Medical School St Louis Missouri Completed
Memorial Sloan Kettering Cancer Center New York New York Recruiting
Nationwide Children's Hosp Columbus Ohio Recruiting
Oregon Health and Science University Portland Oregon Not Yet Recruiting
Children's Hospital of Philadelphia Philadelphia Pennsylvania Completed
UPMC Children's Hospital of Pittsburgh Pittsburgh Pennsylvania Recruiting
Lifespan Cancer Institute Providence Rhode Island Recruiting
University of Texas Southwestern Medical Center at Dallas Dallas Texas Recruiting
Cook Children's Hospital Fort Worth Texas Active Not Recruiting
Texas Childrens Hospital Houston Texas Not Yet Recruiting
University of Texas MD Anderson Cancer Center Houston Texas Recruiting
Seattle Children's Hospital Research Foundation Seattle Washington Recruiting
Medical College of Wisconsin Milwaukee Wisconsin Not Yet Recruiting
Chris O'Brien Lifehouse Camperdown Australia Completed
Peter MacCallum Cancer Centre Melbourne Australia Completed
Royal Children's Hospital Melbourne Australia Completed
UCL- Saint Luc Brussels Belgium Recruiting
Universitair Ziekenhuis Gent Ghent Belgium Completed
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest Bordeaux France Recruiting
Centre Leon Berard Lyon France Not Yet Recruiting
Centre Leon Berard Lyon France Recruiting
Institut Curie Paris France Not Yet Recruiting
Universitaetsklinikum Essen Essen Germany Recruiting

+ 32 more sites — see the full list on the official registry below.

On this site

📄 Verzenio (abemaciclib) drug profile →

More Eli Lilly and Company trials in the UK

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05999994 on ClinicalTrials.gov ↗ ← All trials in the UK