🇮🇪Ireland
16°C Partly Cloudy · Dublin
Live Updates
--:--:-- IST
Writer Login
Latest
Clinical Trials in the UK / NCT04421963
Active, not recruiting Phase 3

Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Olaparib

NCT04421963 · tracked via the Priya Life Science UK tracker
Sponsor
AstraZeneca
Phase
Phase 3
Started
2020-08-04
Last updated
2026-06-12

Condition(s) studied

Ovarian CancerBreast Cancer

Investigational drug(s) / intervention(s)

Olaparib

Olaparib: 300 mg olaparib (2×150 mg tablets) twice daily

Study summary

The rationale of the ROSY-O study is to continue to provide study treatment for patients who have participated in a parent study with olaparib and who are continuing to derive clinical benefit from treatment at the end of such studies, as judged by the Investigator.

Eligibility

Sex
ALL
Min age
18 Years
Max age
99 Years
Healthy volunteers
No
Inclusion Criteria: 1. Provision of signed and dated, written ICF. 2. Patient is currently deriving clinical benefit, as judged by the Investigator, from continued treatment in an AZ parent study using an AstraZeneca (AZ) compound that has met its endpoints or has otherwise stopped. 3. Patient participating in a prior oncology study with an AZ compound in which they received olaparib and are continuing to receive clinical benefit from treatment; the prior study can be an open-label or blinded study, with unblinding at study close. Exclusion Criteria: 1. Ongoing, unresolved, Grade 3 or above toxicity requiring interruption of treatment at the time of the termination of the parent study. 2. Currently receiving treatment with any prohibited medication(s). 3. Concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study. 4. Permanent discontinuation from the parent study due to toxicity or disease progression. 5. Local access to commercially-available drug at no cost to the patient is permitted by local regulation.

Primary outcome measure(s)

Trial sites (107)

FacilityCityRegionStatus
Research Site Boca Raton Florida
Research Site Towson Maryland
Research Site Detroit Michigan
Research Site Minneapolis Minnesota
Research Site Basking Ridge New Jersey
Research Site Hackensack New Jersey
Research Site New York New York
Research Site The Bronx New York
Research Site Philadelphia Pennsylvania
Research Site Pittsburgh Pennsylvania
Research Site Willow Grove Pennsylvania
Research Site Providence Rhode Island
Research Site Germantown Tennessee
Research Site Houston Texas
Research Site Leuven Belgium
Research Site Plovdiv Bulgaria
Research Site Plovdiv Bulgaria
Research Site Sofia Bulgaria
Research Site Halifax Nova Scotia
Research Site Kingston Ontario
Research Site Mississauga Ontario
Research Site Ottawa Ontario
Research Site Toronto Ontario
Research Site Toronto Ontario
Research Site Montreal Quebec
Research Site Montreal Quebec
Research Site Montreal Quebec
Research Site Montreal Quebec
Research Site Québec Quebec
Research Site Changchun China
Research Site Brno Czechia
Research Site Brno Czechia
Research Site Olomouc Czechia
Research Site Ostrava Poruba Czechia
Research Site Prague Czechia
Research Site Prague Czechia
Research Site Aalborg Denmark
Research Site Kuopio Finland
Research Site Lille France
Research Site Lyon France

+ 67 more sites — see the full list on the official registry below.

On this site

📄 Lynparza (olaparib) drug profile →

More AstraZeneca trials in the UK

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04421963 on ClinicalTrials.gov ↗ ← All trials in the UK