Hypotension on InductionCardiac SurgeryAntihypertensive AgentsAnesthesia, IntravenousHemodynamics
Investigational drug(s) / intervention(s)
Chronic Antihypertensive Medication Use
Chronic Antihypertensive Medication Use: Patients' chronic antihypertensive drug use (number of drugs and pharmacological classes) will be recorded. This is an observational study where existing medication regimens (ACE inhibitors, ARBs, Beta-blockers, Calcium Channel Blockers, Diuretics) are documented to analyze their impact on the post-induction hypotension burden (MAP \< 55 mmHg).
Study summary
This study aims to investigate the impact of multiple preoperative antihyperstensive drug use on the burden of post-induction hypotension (PIH) in patients undergoing elective cardiac surgery. The researchers will observe whether the combination of different antihypertensive classes (such as ACE inhibitors, ARBs, beta-blockers, and calcium channel blockers) leads to a higher incidence and severity of blood pressure drops and increased need for vasoactive support during the period between anesthesia induction and surgical incision.
Eligibility
Sex
ALL
Min age
40 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Adult patients aged 40 years and older
* Undergoing elective cardiac surgery (e.g., isolated CABG, isolated valve surgery, or combined CABG+valve surgery via sternotomy)
* Regular use of at least one antihypertensive medication for at least 4 weeks prior to the operation date
* Voluntary participation and signed informed consent
Exclusion Criteria:
* Emergency surgery
* Preoperative shock or requirement for high-dose inotropic/vasopressor therapy
* End-stage liver or kidney failure
* Uncontrolled hypertension
* Difficult intubation or prolonged induction process
* Ejection fraction less than 35%
Primary outcome measure(s)
Post-induction Hypotension (PIH) Burden — From the start of anesthesia induction until 15 minutes post-induction or until central venous catheter placement, whichever occurs first. The hypotension burden is defined as the area under the threshold (AUT) for a mean arterial pressure (MAP) \<55 mmHg. It is calculated using the formula: AUT\<55 = ∫(55 - MAP(t))dt for all values where MAP is below 55 mmHg. This measure integrates both the severity and duration of hypotension.
Trial sites (1)
Facility
City
Region
Status
University of Health Sciences, Konya City Hospital
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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