Multiple SclerosisReliability and ValidityDual Task
Study summary
his study aims to examine the validity and reliability of the Timed Up and Go (TUG) test in patients with Multiple Sclerosis (MS) under dual-task conditions, where participants perform both a motor and a cognitive task at the same time. MS affects movement, balance, and cognitive functions, which can lead to difficulties in walking and increased risk of falls.
In this study, volunteers with MS will be asked to perform the TUG test in different conditions:
Single-task TUG: walking, standing up, and sitting down without additional tasks.
Cognitive dual-task TUG: performing TUG while doing a cognitive task, such as counting backwards or word generation.
Motor dual-task TUG: performing TUG while carrying a small object on a tray.
Participants' demographic and clinical information will be recorded, and tests will be repeated to evaluate the reliability of the measurements. The results will help determine if the TUG test can reliably assess both motor and cognitive performance in MS patients.
The study is observational, and no experimental treatment will be given. Participation involves only performing tests and answering questions, taking approximately 25-30 minutes per session. All collected data will be kept confidential.
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria:
* Diagnosed with Multiple Sclerosis (MS).
* Age 18 years or older.
* EDSS score low to moderate (able to walk without assistive devices).
* Willing to provide informed consent.
* Able to perform Timed Up and Go (TUG) test.
Exclusion Criteria:
* Severe cognitive impairment preventing understanding of instructions.
* Recent MS relapse (within the past 30 days).
* Use of walking aids that interfere with TUG test performance.
* Other neurological or musculoskeletal conditions affecting walking or balance.
* Any condition that makes participation unsafe, according to the investigato
Primary outcome measure(s)
Sit-to-Stand and Walk Test (SKYT) — 1 week SKYT is a test that assesses an individual's functional mobility, balance, and walking performance, including sitting, standing up, walking, turning, and sitting back down. The participant is asked to walk 3 metres and
Dual-task SKYT tests — one weeks Dual-task SKYT tests will consist of three different dual-task SKYT tests: two cognitive dual-task SKYT tests (cSKYT) and one motor dual-task SKYT test (mSKYT). The cognitive task parameters of the cSKYT will be numerical processing
The 25-step walk test (S25AYT) — one weeks This is a standardised test used to assess walking speed and functional mobility in MS patients, performed by walking a distance of 7.62 metres as quickly and safely as possible. The test has been reported to have high rel
Dual-task questionnaire — one weeks The questionnaire was originally developed to assess individuals with neurological injury or disease and is used to evaluate the frequency of difficulties experienced in daily activities involving dual tasks. The questionnaire consists of 10 items, and each question is rated on a 5-point scale (0 = 'never' to 4 = 'very often' or N/A = 'not applicable'). The resulting score is the average score per question (questionnaire score = total questionnaire score/10). Its validity and reliability in the Turkish MS population have been demonstrated.
Mini-BESTest — one weeks A test frequently used in neurological disease populations that assesses the dynamic components of balance control. Participants are asked to perform various balance tasks (e.g., postural responses, sensorimotor strategies, dynamic walking). Studies conducted in MS patients have demonstrated that the Mini-BESTest has high reliability and validity in the Turkish neurological population, including MS.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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