Physical Impairments in Premature Ventricular Complex

Inclusion Criteria for Individuals with Premature Ventricular Complexes (PVCs): * Aged between 18 and 80 years * Presence of symptomatic premature ventricular complexes resistant to ≥1 antiarrhythmic medication (including β-blockers and calcium channel blockers) * Premature ventricular complex burden ≥10% * Ventricular arrhythmias originating from any focus within the right or left ventricle * Physically able to participate in all study assessments * Willingness to participate in the study by providing written informed consent Inclusion Criteria for Control Group Participants: * Aged between 18 and 80 years * Healthy individuals * Willingness to participate in the study * Physically able to participate in all study assessments Exclusion Criteria for Individuals with Premature Ventricular Complexes (PVCs): * Left ventricular ejection fraction (LVEF) \<45% unless PVC-induced cardiomyopathy is documented (defined as a \>15% improvement in LVEF following reduction of PVC burden through pharmacological therapy or ablation) * Progressive decline in LVEF within the last 4 months, regardless of etiology * Severe heart failure classified as New York Heart Association (NYHA) Class ≥III * Ventricular arrhythmias attributed to underlying structural heart disease, known myocardial scar, or myocarditis * Change in the dosage of antiarrhythmic medications (including β-blockers and calcium channel blockers) within 2 months prior to enrollment * Failed catheter ablation within 3 months prior to enrollment * Known thyroid disorders or individuals undergoing renal dialysis * Life expectancy \<12 months * Presence of angina pectoris * Diagnosis of chronic obstructive pulmonary disease (COPD) or asthma * Resting heart rate \>120 beats/min * Resting systolic blood pressure ≥180 mmHg * Resting diastolic blood pressure ≥100 mmHg * Resting peripheral oxygen saturation ≤90% Exclusion Criteria for Control Group Participants: * Presence of premature ventricular complexes * Presence of any acute or chronic medical condition