Inflammatory Biomarkers as Predictors of PONV Following Pediatric Orchiopexy

Condition(s) studied

Investigational drug(s) / intervention(s)

Measurement of Preoperative Inflammatory Biomarkers: Blood samples will be collected preoperatively to measure inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index, monocyte-to-lymphocyte ratio (MLR), and systemic inflammation response index. These values will be analysed in relation to the incidence of postoperative nausea and vomiting within the first 6 hours after pediatric orchiopexy. No experimental drug or device will be administered as part of the study; all procedures will be conducted within the scope of standard perioperative care.

Study summary

Orchiopexy is a common surgical procedure for the treatment of cryptorchidism in the pediatric population, with a high incidence of postoperative nausea and vomiting (PONV).

Recent evidence suggests that systemic inflammation may contribute to PONV pathogenesis, and preoperative inflammatory biomarkers such as NLR, PLR, SII, MLR, and SIRI could serve as predictive indicators.

This prospective observational study aims to evaluate the relationship between these biomarkers and PONV incidence in children undergoing orchiopexy.

Eligibility

Primary outcome measure(s)

• Incidence of Postoperative Nausea and Vomiting (PONV) — Within 6 hours postoperatively
  PONV will be assessed using a standardized nausea-vomiting scoring system by an anesthesiologist blinded to biomarker results.

Trial sites (1)

More Diskapi Yildirim Beyazit Education and Research Hospital trials in Turkey

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