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Clinical Trials in Turkey / NCT06865378
Enrolling by invitation Observational

The Correlation Between Intraoperative End Tidal Carbon Dioxide, Perfusion Index and Pulse Variability Index on Postoperative Nausea Vomiting and Pain

NCT06865378 · tracked via the Priya Life Science Turkey tracker
Phase
Observational
Started
2021-03-15
Last updated
2025-03-07

Condition(s) studied

Postoperative Nausea and VomitingPostoperative Pain, AcuteEnd Tidal Carbon DioxidePerfusion Index and Pleth Variability Index

Investigational drug(s) / intervention(s)

Carbon dioxide (CO2) gas insufflation

Carbon dioxide (CO2) gas insufflation: Artificial pneumoperitoneum created by the Trendelenburg position and carbon dioxide (CO2) insufflation, which is widely used in laparoscopic procedures, frequently leads to physiological changes such as postoperative nausea and vomiting (PONV) and pain. Therefore, the currently limited usable parameters PI and PVI will be evaluated in correlation with end tidal CO2 in continuous monitoring.

Study summary

Postoperative pain, which is frequently encountered in laparoscopic operations, has been examined in different studies with end tidal CO2 (end tidal carbon dioxide), total insufflated gas amount and PI (Perfusion index) parameters. PONV (postoperative nausea and vomiting), which is encountered more frequently than pain in the postoperative period, has been examined in relation to end tidal CO2. In this study, it was aimed to evaluate the development of postoperative pain and PONV, which affect recovery and patient comfort, by comparing the relationship between end tidal CO2, PI and PVI (Pulse variability index).

Eligibility

Sex
FEMALE
Min age
20 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria: * Planned for elective total laparoscopic hysterectomy * 20-65 years old * ASA I - II Exclusion Criteria: * history of intracranial disease * lung disease * systemic hypertension * ischemic heart disease * history of postoperative nausea and vomiting in previous operations * smoking habit * motion sickness * liver and kidney dysfunction * abnormal fluid-electrolyte balance * preoperative use of antiemetic drugs * severe heart failure * ASA III and above * body mass index\> 35 kg m2

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Sağlık Bilimleri Üniversitesi Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi Istanbul Turkey (Türkiye)

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06865378 on ClinicalTrials.gov ↗ ← All trials in Turkey