Effects of Lurasidone on Left Ventricle Systolic Functions

Condition(s) studied

Investigational drug(s) / intervention(s)

Global Longitudinal Strain: Global longitudinal strain measurement is a more objective method to determine left ventricular systolic function than traditional eyeballing method. It helps to detect and quantify subtle changes even so it is an emerging method to evaluate the cardiotoxicity of chemotherapeutic drugs. It is planned to compare each selected patient's GLS measurement before starting to use lurasidone and after six months of using it. Hereby our aim is to find if lurasidone has any effect on left ventricular systolic function.

Study summary

The goal of our study to learn if lurasidone molecule which is used on patients with schizophrenia or bipolar disorder has any cardiotoxic effect.

Eligibility

Primary outcome measure(s)

• Lurasidone molecule will affect left ventricular systolic function — All patients whom are admitted by our psychiatry clinic for the next 6 months will be included.
  We will measure left ventricular global longitudinal strain of each selected patient before starting to use lurasidone and perform the same evaluation for every patient six months later. Since global longitudinal strain measurement is a preferred way to detect subtle changes of wall motions and contractile functions, we will be able detect if this molecule has any negative effect on left ventricular systolic function.

Trial sites (1)

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