The Effect of Sedoanalgesia and General Anaesthesia on Early Neurological Recovery in Acute Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy
Sedoanalgesia: In Acute Ischemic Stroke Patients Undergoing Endovascular Thrombectomy, the procedure was performed under sedoanalgesia. The procedure was continued with mean arterial pressure, heart rate, pulse oximetry and BIS monitoring.
general anesthesia: In Acute Ischemic Stroke Patients Undergoing Endovascular Thrombectomy, the procedure was performed under general anesthesia. The procedure was continued with mean arterial pressure, heart rate, pulse oximetry and BIS monitoring.
Study summary
The hypothesis of this study is that sedoanalgesia will provide better early neurological recovery than general anaesthesia in acute ischaemic stroke patients undergoing endovascular thrombectomy and to investigate the haemodynamic data of both anaesthetic methods.
Eligibility
Sex
ALL
Min age
18 Years
Max age
80 Years
Healthy volunteers
No
Inclusion Criteria:
1. Presence of cerebral ischemic embolism within the first 6 hours
2. ASA 1-4
3. Body mass index below 30 kg m-2
4. NIHSS score ≥ 10
5. Presence of isolated/combined occlusion at any level of the anterior circulation internal carotid or middle cerebral artery
Exclusion Criteria:
* Chronic renal failure
* EF less than 40
* Presence of intracranial hemorrhage
* Previous known history of severe neurological disease
* Presence of bleeding diathesis
* Pre-procedure GCS ≤ 8 and intubated patients
* Failure to clearly show the site of vascular occlusion on diagnostic imaging results
* Clinical or imaging evidence of vascular occlusion that is not internal carotid artery or middle cerebral artery
* Absence of gag reflex, loss of airway protective reflex, inadequate saliva swallowing
* History of lung infection, advanced COPD or respiratory failure
* Known history of aspiration due to vomiting,
* Known history of difficult airway
* In the presence of known intolerance or allergy to certain drugs for sedation, analgesia or both
* Previously known carotid artery stenosis
* Pregnant patients
* Patients without consent
Primary outcome measure(s)
scoring systems of neurological findings — Before Endovascular Thrombectomy and after 48 hours NIHSS (National Institutes of Health Stroke Scale), Glasgow coma scale (GCS) and FOUR (Full Outline of UnResponsiveness) scores
effects of both anesthesia management on hemodynamics during the procedure — Before the Endovascular Thrombectomy procedure and until the end of the recovery period (4 hours) Mean arterial pressure, heart rate
Trial sites (1)
Facility
City
Region
Status
Umraniye Education and Research Hospital
Istanbul
Umraniye
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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