Binocular Visual Therapy and Video Games for Amblyopia Treatment.

Condition(s) studied

Investigational drug(s) / intervention(s)

Red/green glasses: The use of red/green glasses and electronic devices for two hours a day during 4 months.

Electronic Tablet: The use of eye patch on the fellow eye and electronic tablet for 2 hours a day during 4 months.

Eye patch: The use of eye patch on the fellow eye and near vision activities for 2 hours a day during 4 months.

Study summary

Amblyopia, or lazy eye, is best defined by the American Academy of Ophthalmology as a unilateral or bilateral reduction of the best corrected visual acuity that occurs in the setting of an otherwise normal eye, or a structural abnormality involving the eye or visual pathway with reduction in visual acuity that cannot be attributed only to the effect of the structural abnormality. Which causes an abnormal visual experience early in life, with consequences such as deficiencies in the ability to perceive contrast and/or movement, visual acuity, accommodation and stereopsis. The treatment of choice consists in patching of the fellow eye 2 hours per day. The disadvantage of this treatment modality is that patients end up not complying and when treatment is interrupted, lazy eye reappears. Amblyopia was thought to be a monocular disease, now a days there are reports of cortical visual paths changes in both eyes (the fellow and amblyopia eye), believing that it might be a monocular consequence of a binocular disease. Following that statement new treatment studies have arisen, stimulating both eyes not only to improve visual acuity in the lazy eye, but to restore binocular function as well. These treatments use videogames in celular phones, computers, or tablets where the fellow eye is exposed to reduced contrast and the lazy eye is exposed to full-contrast. Although the evidence is promising, more studies are needed to establish effectivity and security of this treatment modality.

Eligibility

Primary outcome measure(s)

• Best corrected visual acuity of the amblyopic eye — Basal
  Best corrected visual acuity of the amblyopic eye using the Snellen chart. Measurements will be converted to LogMar values for statistical analysis.
• Best corrected visual acuity of the amblyopic eye — One month of treatment
  Best corrected visual acuity of the amblyopic eye using the Snellen chart. Measurements will be converted to LogMar values for statistical analysis.
• Best corrected visual acuity of the amblyopic eye — Two months of treatment
  Best corrected visual acuity of the amblyopic eye using the Snellen chart. Measurements will be converted to LogMar values for statistical analysis.
• Best corrected visual acuity of the amblyopic eye — Three months of treatment
  Best corrected visual acuity of the amblyopic eye using the Snellen chart. Measurements will be converted to LogMar values for statistical analysis.
• Best corrected visual acuity of the amblyopic eye — Four months of treatment
  Best corrected visual acuity of the amblyopic eye using the Snellen chart. Measurements will be converted to LogMar values for statistical analysis.
• Best corrected visual acuity of the amblyopic eye two months after treatment suspension to determine lazy eye relapses — Two months after treatment suspension.
  Best corrected visual acuity of the amblyopic eye using the Snellen chart. Measurements will be converted to LogMar values for statistical analysis.

Trial sites (1)

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