🇮🇪Ireland
16°C Partly Cloudy · Dublin
Live Updates
--:--:-- IST
Writer Login
Latest
Clinical Trials in India / NCT07431177
Recruiting Phase 2

A Phase IIb Dose-ranging Study to Assess the Efficacy and Safety of GIA632 in Participants With Non-segmental Vitiligo

NCT07431177 · tracked via the Priya Life Science India tracker
Sponsor
Novartis Pharmaceuticals
Phase
Phase 2
Started
2026-03-09
Last updated
2026-09-09

Condition(s) studied

Non-segmental Vitiligo

Investigational drug(s) / intervention(s)

GIA632Placebo

GIA632: GIA632 will be administered during the 48-week core period.

Placebo: Placebo will be administered during the 48-week core period.

Study summary

The main purpose of this multicenter, randomized, double-blind, placebo-controlled Phase 2b study is to investigate the safety and efficacy of GIA632 in participants with NSV and to identify the optimal dose to be promoted into the confirmatory Phase 3 program.

Eligibility

Sex
ALL
Min age
18 Years
Max age
99 Years
Healthy volunteers
No
Inclusion Criteria: * Signed informed consent must be obtained prior to participation in the study * Male or female as assigned at birth ≥ 18 years of age at the time of screening * Individuals with a diagnosis of non-segmental vitiligo and confirmation of diagnosis through physical examination by the investigator * Non-segmental vitiligo, as assessed at screening, as * ≥ 0.5% Body Surface Area (BSA) on the face and F-VASI score ≥ 0.5 * ≥ 3% BSA on non-facial areas (minimum of 3% should be calculated in addition to hands and feet) and T-VASI score = 3 to 60 Exclusion Criteria: * Individuals unable or unwilling to follow the study procedures and/or to complete the study-related questionnaires * Presence of segmental or mixed vitiligo, or other skin comorbidities that may interfere with study assessments (e.g., hypopigmented mycosis fungoides, genetic diseases with pigmentary aberrations \[such as piebaldism, Waardenburg, etc.\], chemical- or druginduced leukoderma, etc.) * Previous exposure to biologic drugs directly targeting IL-15 or IL-15 receptors * Individual who previously attempted or completed depigmentation therapy for NSV * Use of prohibited medication \& treatments. Other protocol-defined inclusion/exclusion criteria may apply

Primary outcome measure(s)

Trial sites (76)

FacilityCityRegionStatus
Cahaba Derm and skin hlth ctr 27 Birmingham Alabama Recruiting
First OC Dermatology Fountain Valley California Recruiting
MedDerm Associates San Diego California Recruiting
Clinical Trials Research Institute Thousand Oaks California Recruiting
Encore Medical Research Hollywood Florida Recruiting
Mayo Clinic Jacksonville Jacksonville Florida Recruiting
Miami Derm and Laser Institute Miami Florida Recruiting
Global Clinical Professionals St. Petersburg Florida Recruiting
Dawes Fretzin Clinical Rea Group Indianapolis Indiana Recruiting
Hamzavi Dermatology Fort Gratiot Michigan Recruiting
Revival Research Institute Troy Michigan Recruiting
Skin Specialists PC Omaha Nebraska Recruiting
Las Vegas Dermatology Las Vegas Nevada Recruiting
Equity Medical The Bronx New York Recruiting
Oregon Medical Research Center Portland Oregon Recruiting
International Clinical Research Tennessee LCC Murfreesboro Tennessee Recruiting
Bellaire Dermatology Associates Bellaire Texas Recruiting
Center for Clinical Studies Houston Texas Recruiting
Austin Inst for Clinical Research Pflugerville Texas Recruiting
ACRC Trials Plano Texas Recruiting
Virginia Clinical Research Norfolk Virginia Recruiting
Novartis Investigative Site Buenos Aires Buenos Aires Recruiting
Novartis Investigative Site Caba Buenos Aires Recruiting
Novartis Investigative Site Rosario Santa Fe Province Recruiting
Novartis Investigative Site Sydney New South Wales Recruiting
Novartis Investigative Site Waitara New South Wales Recruiting
Novartis Investigative Site Melbourne Victoria Recruiting
Novartis Investigative Site Calgary Alberta Recruiting
Novartis Investigative Site Winnipeg Manitoba Recruiting
Novartis Investigative Site Mississauga Ontario Recruiting
Novartis Investigative Site Newmarket Ontario Recruiting
Novartis Investigative Site Toronto Ontario Recruiting
Novartis Investigative Site Québec Quebec Recruiting
Novartis Investigative Site Guangzhou Guangdong Recruiting
Novartis Investigative Site Wuhan Hubei Recruiting
Novartis Investigative Site Beijing China Recruiting
Novartis Investigative Site Shanghai China Recruiting
Novartis Investigative Site Bordeaux France Recruiting
Novartis Investigative Site Brest France Recruiting
Novartis Investigative Site Créteil France Recruiting

+ 36 more sites — see the full list on the official registry below.

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07431177 on ClinicalTrials.gov ↗ ← All trials in India