Nasojejunal Feeding Versus Oral Feeding Following Endoscopic Drainage of Walled Off Pancreatic Necrosis

NCT07395778 · tracked via the Priya Life Science India tracker

Sponsor

Post Graduate Institute of Medical Education and Research, Chandigarh

Phase

Not applicable

Started

2025-10-18

Last updated

2026-02-09

Condition(s) studied

Walled Off Pancreatic NecrosisAcute Pancreatitis (AP)Endoscopic Ultrasound-Guided Drainage

Investigational drug(s) / intervention(s)

endoscopic ultrasonography guided cystogastrostomy

endoscopic ultrasonography guided cystogastrostomy: Nasojejunal tube will be placed post EUS-CG or oral diet would be started after randomization

Study summary

The goal of this randomized control trial is to assess whether nasojejunal feed is better than oral nutrition in patients who are undergoing endoscopic cystogastrostomy of walled off necrosis following acute pancreatitis. It will also try to answer, the incidence of infections and feed tolerance.

The main question it tries to answer is

1. whether nasojejunl feed is better than oral feed in patients undergoing endoscopic cystogastrostomy in walled off necrosis following acute pancreatitis
2. How much infections they develop, whether they are able to tolerate the feed, weight gain and reintervention rates in each group

Eligibility

Sex

ALL

Min age

18 Years

Max age

75 Years

Healthy volunteers

Inclusion Criteria: 1. Patients of acute pancreatitis (AP) with 18-75 years of age 2. Patients with symptomatic WON requiring EUS guided transluminal drainage 3. Provision of written informed consent Exclusion Criteria: 1. Patients with collection not amenable for EUS guided drainage (distance of WON \>1 cm from the gastrointestinal lumen) 2. Known malignancy or immunocompromised state 3. Previous upper gastrointestinal(GI) surgery interfering with absorption 4. Active GI bleeding 5. GI obstruction, ileus or persistent vomiting 6. Patients moribund to undergo endoscopic procedure (Glasgow coma scale \<8 or patients on ventilatory support) 7. Patients with irreversible coagulopathy like platelets \<50,000/mm3 and/or INR\>1.5 8. Pregnant or lactating female

Primary outcome measure(s)

Nutritional failure — 14 days
To compare the rate of nutritional failure at Day 14 between Nasojejunal and oral feeding post endoscopic transmural drainage of WON

Trial sites (1)

Facility	City	Region	Status
Post Graduate Institute of Medical Education and Research (PGIMER)	Chandigarh	India	Recruiting